Catalog

PI3K Phosphoinositide 3-kinases

Inhibitors

Cat.No.	Name	Information
M10443	Linperlisib (YY-20394)	Linperlisib, also known as YY-20394 and PI3Kδ-IN-2, is a potent and selective PI3Kδ inhibitor.
M10186	Leniolisib	Leniolisib (CDZ173) is a potent and selective PI3Kδ inhibitor with IC50 of 11 nM.
M10157	Seletalisib	Seletalisib (UCB5857) is a potent and selective PI3Kδ inhibitor, with IC50 of 12 nM.
M9912	Glaucocalyxin A	Glaucocalyxin A is an ent-kauranoid diterpene from Rabdosia japonica var.
M9767	BAY1082439	BAY1082439 is an orally bioavailable inhibitor of the class I phosphoinositide 3-kinase (PI3K) alpha and beta isoforms with potential antineoplastic activity.
M9753	PQR530	PQR530 is a highly potent dual pan-PI3K/mTORC1/2 inhibitor.
M9752	GDC-0077	GDC-0077 is a potent and selective PI3K inhibitor with IC50 of 0.038 nM.
M9421	Parsaclisib	Parsaclisib (INCB050465) is a potent and selective PI3Kδ inhibitor, with an IC50 of 1 nM at 1 mM ATP.
M9389	740 Y-P	740 Y-P is a potent and cell permeable PI3K activator.
M9178	GSK2292767	GSK2292767 is a potent and selective PI3Kδ inhibitor.
M9017	Bimiralisib	Bimiralisib (PQR309) is an orally bioavailable inhibitor of PI3K and mTOR, with potential antineoplastic activity.
M8998	PIK-III	PIK-III (also known as VPS34-IN2) is a potent and selective inhibitor of VPS34 enzymatic activity, with IC50s of 18 nM and 1.2 μM for VPS34 and PI(3)Kδ, respectively.
M8925	LY3023414	LY3023414 is a selective ATP-competitive inhibitor of PI3Kα and mTOR, DNA-PK, and other class I PI3K family members.
M7555	SAR405	SAR405 is a PIK3C3/Vps34 inhibitor with an IC50 of 1.2 nM. SAR405 also is a proximal inhibitor of the autophagy machinery.
M7538	Tenalisib	Tenalisib (RP6530) is a potent and selective dual PI3Kδ/γ inhibitor with IC50 values of 24.5 nM and 33.2 nM for PI3Kδ and PI3Kγ, respectively. Its selectivity over α and β isoforms are more than 300-fold and 100-fold, respectively.
M7139	PI 828	PI 828 is a pI 3-kinase inhibitor, more potent than LY 294002.
M6307	IPI3063	IPI-3063 is a potent and selective p110δ inhibitor with biochemical IC50 of 2.5 ± 1.2 nM and IC50 values for the other class I PI3K isoforms (p110α, p110β, p110γ) are at least 400-fold higher.
M6304	GDC-0084	GDC-0084 is a brain penetrant inhibitor of PI3K and mTOR.
M6225	GNE-317	GNE-317 is a potent, brain-penetrant PI3K inhibitor.
M6175	Serabelisib	Serabelisib (INK-1117,MLN-1117,TAK-117) is a potent and selective oral PI3Kα isoform inhibitor (IC50 of 21 nmol/L against PI3Kα) that has demonstrated > 100-fold selectivity relative to other class I PI3K family members (PI3Kβ/γ/δ) and mTOR, and a high degree of selectivity against many other kinase.
M6152	SF2523	SF2523 is a highly selective and potent inhibitor of PI3K with IC50 values of 34 nM, 158 nM, 9 nM, 241 nM and 280 nM for PI3Kα, PI3Kγ, DNA-PK, BRD4 and mTOR, respectively.
M6084	IPI549 (Eganelisib)	IPI549 is a potent and selective PI3Kγ Inhibitor with IC50 of 16 nM.
M5344	VPS34-IN1	Vps34-IN1 is a potent and highly selective Vps34 inhibitor with IC50 of 25 nM invitro,which does not significantly inhibit the isoforms of class I as well as class II PI3Ks.
M5343	Voxtalisib Analogue	Voxtalisib (SAR245409, XL765) Analogue is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.
M5337	PI-3065	PI-3065 is a novel potent and selective PI3K p110δ inhibitor with IC50 of 15 nM; exhibits > 100 fold selectivity against p110α, p110β, p110γ, DNA-PK and mTOR
M5335	PF-4989216	PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM for p110α, p110β, p110γ, p110δ, and VPS34, respectively.
M5314	AZD-8835	AZD8835 ia a novel mixed inhibitor of PI3Kα and PI3Kδ with IC50 of 6.2 nM and 5.7 nM, respectively, also with selectivity against PI3Kβ (IC50=431 nM) and PI3Kγ (IC50=90 nM).
M5268	TGR-1202 (Umbralisib)	TGR-1202, a novel, next generation PI3Kδ inhibitor, inhibits PI3Kδ activity in enzyme and cell based assays with IC50 and EC50 values of 22.2 & 24.3 nM, respectively.
M5255	GDC-0326	GDC-0326 is Inhibitor of the class I phosphoinositide 3-kinase (PI3K) isoform PI3Kα which has received substantial attention for their potential use in cancer therapy.
M5231	GSK2269557	Nemiralisib, also known as GSK-2269557, is a potent and selective PI3Kδ inhibitor(pKi = 9.9).
M4803	AZD8186	AZD8186 is a novel potent small molecule that targets the lipid kinase PI3Kβ with selectivity vs PI3Kα.
M3902	Quercetin	Quercetin is a PI3K inhibitor with IC50 of 2.4-5.4 μM that has been shown to cause potent reversible inhibition of fatty-acid synthase.
M3880	Acalisib	Acalisib (GS-9820) is an inhibitor of the beta and delta isoforms of the 110 kDa catalytic subunit of class IA phosphoinositide-3 kinases (PI3K) with potential immunomodulating and antineoplastic activities.
M3765	NVP-QAV-572	NVP-QAV-572 is a potent PI3K kianse inhibitor with IC50 of 10 nM.
M3730	CNX-1351	CNX-1351 is a selective covalent Inhibitor of PI3Kα.
M3679	AMG 511	AMG 511, a potent and selective pan class I PI3K inhibitor exhibiting IC50 values of 8, 11, 2, and 6 nM against the PI3K α, β, δ, and γ isoforms respectively.
M3531	PIK-294	PIK-294 is a highly selective p110δ inhibitor with IC50 of 10 nM, 1000-, 49- and 16-fold less potent to PI3Kα/β/γ, respectively.
M3474	PIK-93	PIK-93 is the first potent, synthetic PI4K (PI4KIIIβ) inhibitor with IC50 of 19 nM; shown to inhibit PI3Kα with IC50 of 39 nM.
M3450	PIK-293	PIK-293 is a PI3K inhibitor, mostly for PI3Kδ with IC50 of 0.24 μM, 500-, 100- and 50-fold less potent to PI3Kα/β/γ, respectively.
M3368	AS-604850	AS-604850 is a selective, ATP-competitive PI3Kγ inhibitor with IC50 of 250 nM, over 80-fold selectivity for PI3Kγ than PI3Kδ/β, and 18-fold more selective for PI3Kγ than PI3Kα.
M3367	CAY10505	CAY10505 is dehydroxyl of AS-252424, which is a PI3Kγ inhibitor with IC50 of 33 nM.
M3304	YM201636	YM201636 is a selective PIKfyve inhibitor with IC50 of 33 nM, less potent to p110α and insensitive to Fabl (yeast orthologue).
M3230	D-87503	D-87503 inhibits PI3K and Erk2 with IC50 of 62 nM and 760 nM, respectively.
M3218	PKI-402	PKI-402 is a potent dual pan-PI3K/mTOR inhibitor targeting PI3Kα/β/γ/δ and mTOR with IC50 of 2 nM/7 nM/16 nM/14 nM and 3 nM, respectively; also potent to PI3Kα mutants E545K and H1047R.
M3063	TG100713	TG100713 is a pan-PI3K inhibitor against PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ with IC50 of 50 nM, 24 nM, 165 nM and 215 nM, respectively.
M3007	SF1126	SF1126 is a soluble, vascular targeted pan-PI3K inhibitor.
M2609	CZC24832	CZC24832 is the first selective PI3Kγ inhibitor with IC50 of 27 nM, with 10-fold selectivity over PI3Kβ and >100-fold selectivity over PI3Kα and PI3Kδ.
M2567	VS-5584	VS-5584 (SB2343) is a potent and selective dual PI3K/mTOR inhibitor for mTOR, PI3Kα/β/δ/γ with IC50 of 3.4 nM and 2.6-21 nM, respectively.
M2436	BAY 80-6946	BAY 80-6946 is a potent and highly selective reversible PI3K inhibitor for PI3Kα/β with IC50 of 0.469 nM/3.72 nM.
M2296	3-Methyladenine (3-MA)	3-Methyladenine (3-MA) is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM, respectively.

Signaling Pathways

Product Type

PI3K Phosphoinositide 3-kinases

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