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PI3K Phosphoinositide 3-kinases

Cat.No.  Name Information
M2050 GSK2636771 GSK2636771 is a potent, orally available and specific PI3K p110β (PI3K beta, PI3Kβ) inhibitor.
M1925 LY294002 LY294002 is a highly selective PI3K inhibitor with IC50 values of 0.31, 0.73, 1.06 and 6.60 μM for PI3Kβ, PI3Kα, PI3Kδ and PI3Kγ respectively. LY294002 also inhibits CK2 with an IC50 of 98 nM. LY294002 is a competitive DNA-PK inhibitor that binds reversibly to the kinase domain of DNA-PK with an IC50 of 1.4 μM.
M2296 3-Methyladenine (3-MA) 3-Methyladenine (3-MA) is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 μM and 60 μM, respectively.
M1715 GDC-0941 (Pictilisib) GDC-0941 is a selective and potent inhibitor of Class I PI3K, p110a IC50=0.003uM, U87MG IC50=0.95μM.
M1984 PF-04691502 PF-04691502 is a potent and selective, ATP-competitive PI3K/mTOR inhibitor with IC50 of 7.5 nM and 3.8 nM of AKT T308 and AKT S473, respectively.
M2053 Wortmannin (KY 12420) Wortmannin (KY 12420) is a specific, covalent inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) with IC50 of 3 nM.
M1680 BKM120 (Buparlisib) BKM120 (NVP-BKM120) is a potent and highly specific oral pan-class I PI3K inhibitor.
M1819 A66 A66 is a potent and specific inhibitor of PI3K p110α with IC50 values of 32, 30 and 43 nM for p110α, p110α/E545K and p110α/H1047R.
M1671 BEZ235 BEZ235 (NVP-BEZ235) is a potent dual PI3K and mTOR inhibitor of p110α, p110γ, p110δ and p110β with IC50 of 4 nM, 5 nM, 7 nM and 75 nM, respectively.
M1773 PI-103 PI-103 is a potent, ATP-competitive PI3K,cell-permeable,inhibitor.The IC50 values are 2, 8, 20, 26, 48, 83, 88, 150 nM for DNA-PK, p110α, mTORC1, PI3-KC2β, p110δ, mTORC2, p110β, and p110γrespectively.
M2135 GDC-0032 GDC-0032 is a potent, next generation PI3-kinase inhibitor.
M2073 Duvelisib (IPI-145) Duvelisib (IPI-145) is a potent, oral inhibitor of phosphoinositide-3-kinase (PI3K)-delta and PI3K-gamma.
M1978 GSK1059615 GSK1059615 is a potent, ATP-competitive inhibitor of PI 3-kinase alpha (PI3Kα) with IC50 of 2 nM.
M1945 CAL-101 (Idelalisib) CAL-101 (Idelalisib; GS-1101) is an oral PI3Kδ-specific inhibitor that has shown preclinical and clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia.
M1933 GNE-493 GNE-493 is a potent, selective and orally available pan-PI3-kinase and dual pan-PI3-kinase/mTOR inhibitor for the treatment of cancer.
M1931 GSK2126458 GSK2126458 is a highly potent inhibitor of phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) with low picomolar to subnanomolar activity.
M1896 PIK-90 PIK-90 is a novel and potent PI3K inhibitor with IC50 values of 11 nM, 350 nM, 18 nM and 58 nM for p110α, p110β, p110γ and p110δ respectively.
M1886 TG100-115 TG100-115 is a selective PI3K γ/δ inhibitor with IC50 values of 83 and 235 nM respectively.
M1879 XL147 XL147 (SAR245408) is an orally bioavailable, selective small molecule Class I PI3K kinase family inhibitor.
M1878 ZSTK474 ZSTK474 is an ATP-competitive inhibitor of class I phosphatidylinositol 3-kinase (PI3K), induces G1 arrest of the cell cycle in vivo.
M1849 Voxtalisib (XL765) Voxtalisib (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.
M1788 IC87114 IC87114 is a compound that inhibits the p110δ isoform of PI3K selectively, p110δ(IC50 = 0.13 µM) vs. p110α(IC50 = 200 µM), p110β(IC50 = 16 µM) and p110γ(IC50 = 61 µM).
M1772 PKI-587 PKI-587 (PF-05212384) is a highly potent dual PI3K/mTOR kinase inhibitor with the IC50 value of 0.4nM.
M1770 PIK-75 Hydrochloride PIK-75 Hydrochloride is a PI3K p110α specific inhibitor with IC50s of 6,1300,76,510 nM for p110α,p110β,p110γ, p110δrespectively.
M1739 PKI-179 PKI-179 is an orally dual phosphatidylinositol-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor with potential antineoplastic activity.
M1736 CH5132799 CH5132799 is a novel and potent class I PI3K inhibitor with IC50 value of 0.014 μM.
M1735 BGT226 maleate BGT226 (NVP-BGT226) is a novel phosphoinositide 3-kinase/mTOR dual inhibitor.
M1727 Apitolisib (GDC-0980) Apitolisib (GDC-0980; GNE 390; RG 7422) is a potent, highly selective, oral, dual inhibitor of class I PI3K and mTOR.
M1718 AS-252424 AS-252424 is a furan-2-ylmethylene thiazolidinedione as a selective ATP-competitive PI3Kγ inhibitor with IC50 with 33 nM.
M49898 SNV4818 SNV4818 is a potential best-in-class (best-in-class) mutation-selective PI3K-α inhibitor with excellent selectivity for the H1047X mutant and moderate selectivity for the related E545/542X mutant.




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