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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M9645 | Licochalcone D | Licochalcone D is a potent inhibitor of NF-kappaB (NF-κB) p65 with antioxidant, anti-inflammatory, anti-cancer properties. |
| M9456 | Berbamine dihydrochloride | Berbamine dihydrochloride is a novel inhibitor of NF-κB, inhibits growth and induces apoptosis in human myeloma cells. |
| M8600 | Urolithin B | Urolithin B is a natural product with antiproliferative and antioxidant activity. |
| M6180 | AZD3264 | AZD3264 is a novel IKK2 inhibitor. |
| M6179 | Diethylmaleate | Diethylmaleate is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NF-kB. |
| M5580 | Dimethyl Fumarate | Dimethyl fumarate(DMF) is a nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator; induces upregulation of antioxidant gene expression. |
| M5371 | 5-Aminosalicylic acid | 5-Aminosalicylic acid is a specific inhibitor of TNFα-induced IKK activity, used to treat inflammatory bowel disease. |
| M5232 | GSK583 | GSK583 is a highly potent and selective inhibitor of RIP2 kinase with an IC50 of 5 nM. |
| M4940 | SC75741 | SC75741 is a potent NF-κB inhibitor with EC50 of 200 nM. |
| M4005 | PDTC | PDTC is a selective nuclear factor-κB (NF-κB) inhibitor. |
| M3963 | Bruceine A | Bruceine A, a natural quassinoid compound extracted from the dried fruits of Brucea javanica (L.) Merr., was evaluated for its antibabesial activity in vitro and in vivo. |
| M3930 | Parthenolide | Parthenolide (PTL) is a sesquiterpene lactone isolated from feverfew and exhibits potent antitumor activity against various cancers. |
| M3161 | Betulinic acid | Betulinic acid is a pentacyclic triterpene which selectively induces apoptosis in tumor cells. It acts as a new activator of NF-kB. |
| M3017 | Sodium 4-Aminosalicylate | Sodium 4-Aminosalicylate is an antibiotic used to treat tuberculosis via NF-κB inhibition and free radical scavenging. |
| M2786 | JSH-23 | JSH-23 is an inhibitor of NF-κB transcriptional activity with IC50 of 7.1 μM. |
| M2484 | Caffeic Acid Phenethyl Ester | Caffeic acid phenethyl ester is a potent and specific inhibitor of NF-κB activation, and also displays antioxidant, immunomodulatory and antiinflammatory activities. |
| M2298 | QNZ | QNZ is an inhibitor of NF-κB activation with IC50 of 11 nM. |
| M2197 | Sulfasalazine | Sulfasalazine is an inhibitor of NF-κB activation and a procompound of the anti-inflammatory agent 5-aminosalicylic acid. |
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