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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M4005 | Pyrrolidinedithiocarbamate ammonium (PDTC) | Pyrrolidinedithiocarbamate ammonium (PDTC) is a selective nuclear factor-κB (NF-κB) inhibitor. |
| M5580 | Dimethyl Fumarate | Dimethyl fumarate(DMF) is a nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator; induces upregulation of antioxidant gene expression. |
| M4940 | SC75741 | SC75741 is a broad and potent INHIBITOR of NF-κB with an IC50 of 200 nM against P65. SC75741 blocks replication of influenza viruses. SC75741 leads to decreased expression of cytokines, chemokines, and pro-apoptotic factors by impairing DNA binding of NF-κB subunit P65. Inhibit caspase activation and block caspase-mediated nuclear output of viralribonucleoproteins. |
| M21403 | CORM-3 | CORM-3 is a carbon monoxide-releasing molecule that attenuates nuclear ectopic NF-κB p65, reduces ROS production, and increases intracellular glutathione and superoxide dismutase levels.CORM-3 reduces the activation of NLRP3 inflammatory vesicles. |
| M20672 | INH14 | INH14 is an inhibitor of TLR2-mediated NF-kB activation with IC50 values of 8.975 μM and 3.598 μM for IKKα and IKKβ, respectively. |
| M14612 | Tomatidine hydrochloride | Tomatidine hydrochloride acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. Tomatidine hydrochloride activates autophagy either in mammal cells or C elegans. |
| M14611 | Tomatidine | Tomatidine acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. Tomatidine activates autophagy either in mammal cells or C elegans. |
| M14610 | Stachydrine hydrochloride | Stachydrine hydrochloride is the major active constituent of Herba Leonuri, which is a potential therapy for cardiovascular diseases. Stachydrine can inhibit the NF-κB signal pathway. Anti-hypertrophic activities. |
| M14609 | Stachydrine | Stachydrine is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis. Stachydrine can inhibit the NF-κB signal pathway. |
| M14608 | Sinomenine | Sinomenine, an alkaloid extracted from Sinomenium acutum, is a blocker of the NF-κB activation. Sinomenine also is an activator of μ-opioid receptor. |
| M14607 | Rocaglamide | Rocaglamide (Roc-A) is isolated from the genus Aglaia and can be used for coughs, injuries, asthma and inflammatory skin diseases. |
| M14606 | Quinoclamine | Quinoclamine, a naphthoquinone derivative, is a NF-κB inhibitor. Quinoclamine exhibits anti-cancer activity. |
| M14605 | Micheliolide | Micheliolide could effectively attenuate the high glucose-stimulated activation of NF-κB, the degradation of IκBα, and the expression of MCP-1, TGF-β1 and FN in rat mesangial cells (MCs). |
| M14604 | Isoliquiritin apioside | Isoliquiritin apioside significantly decreases PMA-induced increases in MMP9 activities and suppresses PMA-induced activation of MAPK and NF-κB. |
| M14603 | Indole-3-carbinol | Indole-3-carbinol (I3C) inhibits NF-κB activity and also is an Aryl hydrocarbon receptor (AhR) agonist, and an inhibitor of WWP1 (WW domain-containing ubiquitin E3 ligase 1). |
| M14602 | FW1256 | FW1256 is a phenyl analogue and a slow-releasing hydrogen sulfide (H2S) donor. |
| M14601 | Erdosteine | Erdosteine inhibits lipopolysaccharide (LPS)-induced NF-κB activation. Erdosteine has muco-modulatory, anti-bacterial, anti-inflammatory and anti-oxidant effects. |
| M14600 | DCZ0415 | DCZ0415, a potent TRIP13 inhibitor, impairs nonhomologous end joining repair and inhibits NF-κB activity. DCZ0415 induces anti-myeloma activity in vitro, in vivo, and in primary cells derived from drug-resistant myeloma patients. |
| M14599 | Asatone | Asatone is an active component isolated from Radix et Rhizoma Asari, with anti-inflammatory effect via activation of NF-κB and donwn regulation of p-MAPK (ERK, JNK and p38) pathways. |
| M14598 | Inulicin | Inulicin (1-O-Acetylbritannilactone) is an active compound that inhibits VEGF-mediated activation of Src and FAK. |
| M14597 | 14-Deoxy-11,12-didehydroandrographolide | 14-Deoxy-11,12-didehydroandrographolide is an analogue of Andrographolide. 14-Deoxy-11,12-didehydroandrographolide inhibits NF-κB activation. |
| M13449 | Ac2-26 TFA | Ac2-26 TFA, an active N-terminal peptide of adiponectin A1 (AnxA1), alleviates acute lung injury induced by ischemia-reperfusion. Ac2-26 also decreased AnxA1 protein expression and inhibited the activation of NF-κB and MAPK pathways in damaged lung tissue. Sequence Shortening: Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-GIn-Ala-Trp-Phe-lle-Glu-Asn-Glu-Glu-GIn-Glu-Tyr-Val-GIn-Thr-Val-Lys |
| M11454 | (-)-DHMEQ | (-) - DHMEQ (Dehydroxymethylepoxyquinomicin) is an effective and selective and irreversible nf-kappa B inhibitors, covalent binding and cysteine residues. (-)-DHMEQ inhibited nuclear NF-κB translocation and showed anti-inflammatory and anticancer activity. |
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