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SC75741

Cat. No. M4940
SC75741 Structure
Synonym:

SC-75741

Size Price Availability Quantity
5mg USD 85  USD85 In stock
10mg USD 150  USD150 In stock
25mg USD 300  USD300 In stock
50mg USD 550  USD550 In stock
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Quality Control & Documentation
Biological Activity

SC75741 is a broad and potent INHIBITOR of NF-κB with an IC50 of 200 nM against P65. SC75741 blocks replication of influenza viruses. SC75741 leads to decreased expression of cytokines, chemokines, and pro-apoptotic factors by impairing DNA binding of NF-κB subunit P65. Inhibit caspase activation and block caspase-mediated nuclear output of viralribonucleoproteins.

Product Citations
Chemical Information
Molecular Weight 565.67
Formula C29H23N7O2S2
CAS Number 913822-46-5
Solubility (25°C) DMSO 35 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Emanuel Haasbach, et al. Antiviral Res . The NF-kappaB inhibitor SC75741 protects mice against highly pathogenic avian influenza A virus

[2] Leban J,et.al. Bioorg Med Chem Lett. A novel class of potent NF-kappaB signaling inhibitors.

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Keywords: SC75741, SC-75741 supplier, NF-κB, inhibitors, activators


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