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SC75741

Cat. No. M4940

SC75741 Structure
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

SC75741 (15 mg/kg i.p.) reduces virus replication and cytokine expression in mice lungs after H5N1 influenza virus infection.SC75741 shows immunosuppressive activity by inhibiting human PBMC proliferation with IC50 of 2.2 μM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 565.67
Formula C29H23N7O2S2
CAS Number 913822-46-5
Purity >99%
Solubility DMSO 35 mg/mL warmed
Water <1 mg/mL
Storage at -20°C
References

A novel class of potent NF-kappaB signaling inhibitors.
Leban J,et.al. Bioorg Med Chem Lett. 2007 Nov 1;17(21). PMID: 17869512.

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Keywords: SC75741 supplier, NF-κB, inhibitors

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