SC75741 (15 mg/kg i.p.) reduces virus replication and cytokine expression in mice lungs after H5N1 influenza virus infection.SC75741 shows immunosuppressive activity by inhibiting human PBMC proliferation with IC50 of 2.2 μM.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||DMSO 35 mg/mL warmed
Water <1 mg/mL
A novel class of potent NF-kappaB signaling inhibitors.
Leban J,et.al. Bioorg Med Chem Lett. 2007 Nov 1;17(21). PMID: 17869512.
|Related NF-κB Products|
Dimethyl fumarate(DMF) is a nuclear factor (erythroid-derived)-like 2 (Nrf2) pathway activator; induces upregulation of antioxidant gene expression.
5-Aminosalicylic acid is a specific inhibitor of TNFα-induced IKK activity, used to treat inflammatory bowel disease.
GSK583 is a highly potent and selective inhibitor of RIP2 kinase with an IC50 of 5 nM.
PDTC is a selective NF-kB inhibitor.
Bruceine A, a natural quassinoid compound extracted from the dried fruits of Brucea javanica (L.) Merr., was evaluated for its antibabesial activity in vitro and in vivo.
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