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Dimethyl Fumarate

Cat. No. M5580
Dimethyl Fumarate Structure
Synonym:

DMF; LAS41008

Size Price Availability Quantity
500mg USD 45  USD45 In stock
1g USD 55  USD55 In stock
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Quality Control & Documentation
Biological Activity

Dimethyl Fumarate (DMF) is an orally active Monomethyl fumarate (MMF) precursor compound that is also an Nrf2 pathway activator and inhibits NF-κB. In addition, Dimethyl Fumarate also inhibits GAPDH and can be used in studies related to multiple sclerosis (MS) and psoriasis.

Product Citations
Customer Product Validations & Biological Datas
Source Mediators of Inflammation (2020 Jun). Figure 3. Dimethyl Fumarate (Abmole Bioscience, TX, USA)
Method injections
Cell Lines Mice
Concentrations 5μmol/kg/day
Incubation Time 4 weeks
Results However, CD137 inhibitor or M5580 (an activator of Nrf2) pretreatment could markedly reverse the nuclear translocation of Nrf2 (Figures 3(a) and 3(b)), and the results were confirmed by Western blot (Figure 3(c)). These results indicated that CD137 signaling has inhibitory effect on the nuclear translocation of Nrf2.
Chemical Information
Molecular Weight 144.13
Formula C6H8O4
CAS Number 624-49-7
Solubility (25°C) 9.6 mg/mL in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Iniaghe LO, et al. Neurobiol Dis. Dimethyl fumarate confers neuroprotection by casein kinase 2 phosphorylation of Nrf2 in murine intracerebral hemorrhage.

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Keywords: Dimethyl Fumarate, DMF; LAS41008 supplier, NF-κB, inhibitors, activators


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