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CDDO-dhTFEA

Cat. No. M21470
CDDO-dhTFEA Structure
Synonym:

RTA dh404

Size Price Availability Quantity
5mg USD 185  USD185 In stock
10mg USD 295  USD295 In stock
25mg USD 585  USD585 In stock
50mg USD 875  USD875 In stock
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Quality Control & Documentation
Biological Activity

CDDO-dhTFEA (RTA dh404) is a synthetic oleanane triterpenoid compound that effectively activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB.

Chemical Information
Molecular Weight 574.72
Formula C33H45F3N2O3
CAS Number 1191265-33-4
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Lourdes Robles, et al. Pancreas. Synthetic Triterpenoid RTA dh404 (CDDO-dhTFEA) Ameliorates Acute Pancreatitis

[2] Mohammad A Aminzadeh, et al. Redox Biol. The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores endothelial function impaired by reduced Nrf2 activity in chronic kidney disease

[3] Mohammad A Aminzadeh, et al. Xenobiotica. The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores Nrf2 activity and attenuates oxidative stress, inflammation, and fibrosis in rats with chronic kidney disease

[4] Scott A Reisman, et al. Xenobiotica. CDDO-9,11-dihydro-trifluoroethyl amide (CDDO-dhTFEA) induces hepatic cytoprotective genes and increases bile flow in rats

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Keywords: CDDO-dhTFEA, RTA dh404 supplier, NF-κB, inhibitors, activators


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