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Abmole Inhibitor Catalog 2017

mTOR Mammalian Target Of Rapamycin


Cat.No.  Name Information
M4852 LY303511 LY303511 is a structural analogue of LY294002, which does not inhibit PI3K, increased homotypic GJIC.
M3722 Temsirolimus Temsirolimus (CCI-779) is a specific mTOR inhibitor with IC50 of 1.76 μM.
M3556 WYE-125132 WYE-125132 is a highly potent, ATP-competitive mTOR inhibitor with IC50 of 0.19 nM; highly selective for mTOR versus PI3Ks or PI3K-related kinases hSMG1 and ATR.
M2299 AZD2014 AZD2014 is a novel dual mTORC1 and mTORC2 inhibitor with potential antineoplastic activity.
M2276 Torin 1 Torin 1 is a potent and selective inhibitor of mTOR with IC50 of 2 and 10 nM for mTORC1 and mTORC2, respectively.
M2151 INK128 INK128 (MLN0128) is a potent and selective dual TORC1/2 inhibitor with IC50 of 1 nM.
M2118 XL388 XL388 is a novel, highly potent, ATP-competitive and orally bioavailable mTOR inhibitor.
M2099 OSI-027 OSI-027 is an orally bioavailable, potent and selective inhibitor of mTORC1 and mTORC2 with IC50 values of 22 nM and 65 nM, respectively.
M2094 GDC-0349 GDC-0349 is a potent and selective, ATP-competitive mTOR inhibitor.
M2022 Torin 2 Torin 2 is a potent and selective mTOR inhibitor with IC50 of 2.1 nM.
M1981 PP242 PP242 is a selective, ATP-competitive mTORC1/mTORC2 inhibitor with IC50 of 8 nM.
M1852 WAY-600 WAY-600 is a selective single digit nanomolar ATP-competitive mTOR inhibitor with an IC50 of about 9 nM.
M1768 Rapamycin Rapamycin (Sirolimus,Rapamune)is an inhibitor of mTOR.The mammalian target of rapamycin (mTOR) is a kinase responsible for mitogen-induced cell proliferation/survival signaling.
M1760 Palomid 529 Palomid 529 (P529) is a novel potent PI3K/Akt/mTOR inhibitor and shows a potent antiproliferative activity in the NCI-60 cell lines panel, with growth inhibitory 50 (GI50) <35 μM.
M1756 WYE-687 WYE-687 is a novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin (mTOR) with an IC50 of 7 nM.
M1755 WYE-354 WYE-354 is a cell-permeable pyrazolopyrimidine compound that acts as a potent and ATP-competitive mTOR inhibitor (IC50 = 5 nM with S6K as the substrate and 100 µM ATP).
M1731 KU-0063794 KU-0063794 is a potent and selective mTOR inhibitor with IC50 values of approximately 10 nM for mTORC1 and mTORC2.
M1709 Everolimus Everolimus (RAD001) also known as SDZ-RAD and Certican is an mTOR inhibitor with IC50 of 0.63 nM.
M1703 Deforolimus Deforolimus (also known as AP23573 and MK-8669) is an investigational targeted and small-molecule mTOR inhibitor.
M1666 AZD8055 AZD8055 is a novel ATP-competitive inhibitor of mTOR kinase (both complexes mTORC1 and mTORC2) with an IC50 of 0.8 nM.

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