mTOR Mammalian Target Of Rapamycin

Cat.No.	Name	Information
M1768	Rapamycin	Rapamycin (Sirolimus,Rapamune)is an inhibitor of mTOR.The mammalian target of rapamycin (mTOR) is a kinase responsible for mitogen-induced cell proliferation/survival signaling.
M3722	Temsirolimus	Temsirolimus (WAY-130779, CCI-779) is a specific mTOR inhibitor with IC50 of 1.76 μM.
M1666	AZD8055	AZD8055 is a novel ATP-competitive inhibitor of mTOR kinase (both complexes mTORC1 and mTORC2) with an IC50 of 0.8 nM.
M2151	INK128 (Sapanisertib)	INK128 (Sapanisertib; MLN0128) is a potent and selective dual TORC1/2 inhibitor with IC50 of 1 nM.
M1709	Everolimus	Everolimus (RAD001) also known as SDZ-RAD and Certican is an mTOR inhibitor with IC50 of 0.63 nM.
M9050	MHY1485	MHY1485 is an mTOR activator that potently inhibits autophagy by suppression of fusion between autophagosomes and lysosomes.
M2276	Torin 1	Torin 1 is a potent and selective inhibitor of mTOR with IC50 of 2 and 10 nM for mTORC1 and mTORC2, respectively.
M6130	Zotarolimus	Zotarolimus (ABT-578) is an analogue of rapamycin, and inhibits FKBP-12 binding with IC50 of 2.8 nM.
M4961	CB72666407	Pyrimidine substituted purine compounds as kinase (S) inhibitors.
M4934	Onatasertib (CC-223)	Onatasertib (CC-223) is a potent mTOR kinase inhibitor (IC50=16 nM), with >150-fold sensitivity over the related lipid kinase PI3Kα (IC50=4 μM).
M4852	LY303511	LY303511 is a structural analogue of LY294002, which does not inhibit PI3K, increased homotypic GJIC.
M3899	Salidroside	Salidroside is a phenylpropanoid extracted from Rhodiola rosea that exhibits a protective effect against iron death by activating AMPK. It is also a prolyl endopeptidase inhibitor.
M3556	WYE-125132	WYE-125132 is a highly potent, ATP-competitive mTOR inhibitor with IC50 of 0.19 nM; highly selective for mTOR versus PI3Ks or PI3K-related kinases hSMG1 and ATR.
M2299	AZD2014	AZD2014 is a novel dual mTORC1 and mTORC2 inhibitor with potential antineoplastic activity.
M2118	XL388	XL388 is a novel, highly potent, ATP-competitive and orally bioavailable mTOR inhibitor.
M2099	OSI-027	OSI-027 is an orally bioavailable, potent and selective inhibitor of mTORC1 and mTORC2 with IC50 values of 22 nM and 65 nM, respectively.
M2094	GDC-0349	GDC-0349 is a potent and selective, ATP-competitive mTOR inhibitor.
M2022	Torin 2	Torin 2 is a potent and selective mTOR inhibitor with IC50 of 2.1 nM.
M1981	Torkinib (PP242)	Torkinib (PP242) is a selective, ATP-competitive mTORC1/mTORC2 inhibitor with IC50 of 8 nM.
M1852	WAY-600	WAY-600 is a selective single digit nanomolar ATP-competitive mTOR inhibitor with an IC50 of about 9 nM.
M1760	Palomid 529	Palomid 529 (P529) is a novel potent PI3K/Akt/mTOR inhibitor and shows a potent antiproliferative activity in the NCI-60 cell lines panel, with growth inhibitory 50 (GI50) <35 μM.
M1756	WYE-687	WYE-687 is a novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin (mTOR) with an IC50 of 7 nM.
M1755	WYE-354	WYE-354 is a cell-permeable pyrazolopyrimidine compound that acts as a potent and ATP-competitive mTOR inhibitor (IC50 = 5 nM with S6K as the substrate and 100 µM ATP).
M1731	KU-0063794	KU-0063794 is a potent and selective mTOR inhibitor with IC50 values of approximately 10 nM for mTORC1 and mTORC2.
M1703	Deforolimus	Deforolimus (also known as AP23573 and MK-8669) is an investigational targeted and small-molecule mTOR inhibitor. *The compound is unstable in solutions, freshly prepared is recommended
M50430	Thioether-cyclized helix B peptide, CHBP	Thioether-cyclized helix B peptide, CHBP can improve metabolic stability and renoprotective effect through inducing autophagy via inhibition of mTORC1 and activation of mTORC2.
M43385	mTOR inhibitor-11	mTOR inhibitor-11 is a brain-penetrant mTOR inhibitor (IC50: 21 nM for pS6).

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mTOR Mammalian Target Of Rapamycin

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