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Torin 1

Cat. No. M2276
Torin 1 Structure
Size Price Availability Quantity
10mg USD 120 In stock
25mg USD 280 In stock
50mg USD 470 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Torin 1 is a potent inhibitor of mTORC1/2 with IC50 of 2 nM/10 nM. Torin 1 shows over 100-fold selectivity for mTOR over PI3Kα and other PI3K-like kinases, including ATM, DNA-PK, and hVps34, as well as 450 other protein kinases. Torin 1 induces autophagy in HeLa cells. Torin 1 is efficacious at a dose of 20 mg/kg in inhibiting downstream effectors of mTOR in mice. In a recent study, it is reported Torin 1 increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 607.62
Formula C35H28F3N5O2
CAS Number 1222998-36-8
Purity >99%
Solubility DMSO
Storage at -20°C
References

mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway.
Peterson TR, et al. Cell. 2011 Aug 5;146(3):408-20. PMID: 21816276.

mTORC1 inhibition increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON.
Li J, et al. Am J Physiol Cell Physiol. 2011 Jul;301(1):C213-26. PMID: 21508335.

mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs.
Dowling RJ, et al. Science. 2010 May 28;328(5982):1172-6. PMID: 20508131.

An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1.
Thoreen CC, et al. J Biol Chem. 2009 Mar 20;284(12):8023-32. PMID: 19150980.

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  Catalog
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Keywords: Torin 1 supplier, mTOR, inhibitors

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