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L-Leucine

Cat. No. M10032
L-Leucine Structure
Size Price Availability Quantity
1g USD 20  USD20 In stock
5g USD 25  USD25 In stock
50g USD 60  USD60 In stock
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Quality Control & Documentation
Biological Activity

L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway. Leucine stimulates protein synthesis in skeletal muscle of neonatal pigs by enhancing mTORC1 activation. L-Leucine increases intracellular HIF-1α levels and activates the HIF-1α signaling pathway, and these two effects are mediated by the mTOR signaling pathway. This process results in Ngn3 repression and, consequently, decreases β-cell differentiation.

Chemical Information
Molecular Weight 131.17
Formula C6H13NO2
CAS Number 61-90-5
Solubility (25°C) Water 10 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Latif Rachdi, et al. Diabetes. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway

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Keywords: L-Leucine supplier, mTOR, inhibitors, activators


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