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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M9300 | AG 126 | AG 126 is a cell-permeable inhibitor of lipopolysaccharide (LPS)-induced synthesis of tumor necrosis factor-α and nitric oxide in murine peritoneal macrophages. |
| M9108 | AZD-0364 | AZD-0364 is a potent and selective ERK2 inhibitor with an IC50 of 0.6 nM. |
| M6266 | Pluripotin | Pluripotin (SC1) is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP. Maintains embryonic stem cell (ESC) self-renewal. |
| M6235 | VX-11e | VX-11e is a potent, selective, and orally bioavailable ERK2 inhibitor with Ki of <2 nM, over 200-fold selective over other kinases tested. |
| M6089 | XMD8-92 | XMD8-92 is a potent and selective BMK1/ERK5 inhibitor with Kd of 80 nM. |
| M5345 | VRT752271 | VRT752271 (BVD-523, Ulixertinib) is a potent and reversible ERK1/ERK2 inhibitor with IC50 of <0.3 nM for ERK2. |
| M5340 | Tauroursodeoxycholate Sodium | Sodium Tauroursodeoxycholate (TUDC) is a water soluble bile salt, used for the treatment of gallstones and liver cirrhosis. |
| M5248 | DEL-22379 | DEL-22379 is a water-soluble ERK dimerization inhibitor with IC50 of ∼0.5 μM. |
| M5158 | Tauroursodeoxycholic acid | Tauroursodeoxycholic acid (TUDCA) is an ambiphilic bile acid. |
| M4819 | XMD17-109 | XMD17-109 (ERK5-IN-1) is a novel, specific inhibitor of ERK-5 with an EC50 value of 4.2 μM in HEK293 cells. |
| M4662 | Nitidine chloride | Nitidine chloride is a benzophenanthridine alkaloid found in species of the genus Zanthoxylum with anti-malarial activity. |
| M3668 | GDC-0994 | GDC-0994 is a potent, orally available ERK inhibitor with IC50 1.1 nM and 0.3 nM, respectively. |
| M3642 | FR 180204 | FR 180204 is an ATP-competitive, selective ERK inhibitor with Ki of 0.31 μM and 0.14 μM for ERK1 And ERK2, respectively. |
| M2084 | SCH772984 | SCH772984 is a novel and selective inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively. |
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