Catalog

ERK Extracellular signal-regulated kinase

Inhibitors

Cat.No.	Name	Information
M6266	Pluripotin	Pluripotin (SC1) is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP. Maintains embryonic stem cell (ESC) self-renewal.
M6235	VX-11e	VX-11e is a potent, selective, and orally bioavailable ERK2 inhibitor with Ki of <2 nM, over 200-fold selective over other kinases tested.
M6089	XMD8-92	XMD8-92 is a potent and selective BMK1/ERK5 inhibitor with Kd of 80 nM.
M5345	VRT752271	VRT752271 (BVD-523, Ulixertinib) is a potent and reversible ERK1/ERK2 inhibitor with IC50 of <0.3 nM for ERK2. Phase 1.
M5248	DEL-22379	DEL-22379 is a water-soluble ERK dimerization inhibitor with IC50 of ∼0.5 μM.
M4819	XMD17-109	XMD17-109 is a novel, specific inhibitor of ERK-5 with an EC50 value of 4.2 μM in HEK293 cells.
M3668	GDC-0994	GDC-0994 is a potent, orally available ERK inhibitor with IC50 1.1 nM and 0.3 nM, respectively.
M3642	FR 180204	FR 180204 is an ATP-competitive, selective ERK inhibitor with Ki of 0.31 μM and 0.14 μM for ERK1 And ERK2, respectively.
M2084	SCH772984	SCH772984 is a novel and selective inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively.