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ERK Extracellular signal-regulated kinase

Inhibitors

Cat.No.  Name Information
M2084 SCH772984 SCH772984 is a novel and selective inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively.
M5158 Tauroursodeoxycholic acid Tauroursodeoxycholic acid (TUDCA) is an ambiphilic bile acid.
M11181 2,5-Dihydroxyacetophenone 2',5'-Dihydroxyacetophenone (DHAP, 2-Acetylhydroquinone, Quinacetophenone) is a mixture of dihydroxyacetophenone isomers used in food flavoring. 2',5'-Dihydroxyacetophenone significantly inhibits the production of NO by inhibiting the expression of iNOS. 2',5'-Dihydroxyacetophenone significantly reduces the expression levels of the pro-inflammatory cytokines TNF-α and IL-6 by blocking the ERK1/2 and NF-κB signaling pathways.
M11099 Tenuifoliside A Tenuifoliside A is isolated from Yuanzhi and has anti-apoptotic and antidepressant effects. In C6 cells, Tenuifoliside A exhibits its neurotrophic effects and promotes cell proliferation through the ERK/CREB/BDNF signaling pathway.
M11050 Tauroursodeoxycholate dihydrate Tauroursodeoxycholate (Tauroursodeoxycholic acid; TDUCA) dihydrate is an endoplasmic reticulum stress inhibitor. Tauroursodeoxycholate significantly reduces the expression of apoptotic molecules such as caspase-3 and caspase-12. Tauroursodeoxycholate also suppresses ERK.
M11022 DMU-212 DMU-212 is a resveratrol methylated derivative with anti-division, antiproliferative, antioxidant and apoptosis-promoting activities. DMU-212 causes mitosis to stop by inducing apoptosis and activating the ERK1/2 protein.
M11021 (rel)-AR234960 (rel)-AR234960 is the relatively active configuration of AR234960. AR234960 is a non-peptide MAS (a G protein coupling receptor) agonist that upregulates CTGF mRNA and protein levels through the ERK1/2 signaling pathway in HEK293-MAS cells and adult myocardial fibroblasts.
M10741 ERK1/2 inhibitor 2 ERK1/2 inhibitor 2 (Example 1) is a potent dual ERK1/2 inhibitor. ERK1/2 inhibitor 2 has anti-cancer activity.
M10597 Pamoic acid disodium Pamoic acid disodium is a potent GPR35 agonist with an EC50 value of 79 nM. Pamoic acid disodium induces GPR35 internalization and activates ERK1/2 with EC50 values of 22 nM and 65 nM, respectively.
M10071 KO-947 KO-947 is a potent and selective ERK inhibitor with slow dissociation kinetics.
M9803 MK-8353 MK-8353 (SCH900353) is an orally bioavailable, selective, and potent ERK1/2 inhibitor, with IC50 values of 23.0 nM and 8.8 nM, respectively.
M9688 ERK5-IN-2 ERK5-IN-2 is a selective, orally active, sub-micromolar ERK5 inhibitor with IC50s of 0.82 μM, 3 μM for ERK5 and ERK5 MEF2D, respectively.
M9510 JWG-071 JWG-071 is the first reported kinase-selective chemical probe for ERK5, inhibits ERK5 and LRRK2 with IC50 of 88 and 109 nM, respectively.
M9300 AG 126 AG 126 is a cell-permeable inhibitor of lipopolysaccharide (LPS)-induced synthesis of tumor necrosis factor-α and nitric oxide in murine peritoneal macrophages.
M9108 AZD-0364 AZD-0364 is a potent and selective ERK2 inhibitor with an IC50 of 0.6 nM.
M6266 Pluripotin Pluripotin (SC1) is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP. Maintains embryonic stem cell (ESC) self-renewal.
M6235 VX-11e VX-11e is a potent, selective, and orally bioavailable ERK2 inhibitor with Ki of <2 nM, over 200-fold selective over other kinases tested.
M6089 XMD8-92 XMD8-92 is a potent and selective BMK1/ERK5 inhibitor with Kd of 80 nM.
M5345 Ulixertinib (BVD-523) VRT752271 (BVD-523, Ulixertinib) is a potent and reversible ERK1/ERK2 inhibitor with IC50 of <0.3 nM for ERK2.
M5340 Tauroursodeoxycholate Sodium Sodium Tauroursodeoxycholate (TUDC) is a water soluble bile salt, used for the treatment of gallstones and liver cirrhosis.
M5248 DEL-22379 DEL-22379 is a water-soluble ERK dimerization inhibitor with IC50 of ∼0.5 μM.
M5158 Tauroursodeoxycholic acid Tauroursodeoxycholic acid (TUDCA) is an ambiphilic bile acid.



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