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Tauroursodeoxycholic acid

Cat. No. M5158
Tauroursodeoxycholic acid Structure
Synonym:

TUDCA

Size Price Availability Quantity
100mg USD 80 In stock
500mg USD 160 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Tauroursodeoxycholic acid (TUDCA) is an ambiphilic bile acid. TUDCA is the taurine conjugate form of ursodeoxycholic acid (UDCA). TUDCA has been used in ancient Asian pharmacopoeias for its supposed beneficial effects. Ongoing research is finding TUDCA has diminishing apoptotic effects, helping with cardiac function, Huntington's disease, Parkinson's Disease, and stroke.

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 499.7
Formula C26H45NO6S
CAS Number 14605-22-2
Purity >98%
Solubility
Storage at -20°C
References

Administration of tauroursodeoxycholic acid (TUDCA) reduces apoptosis following myocardial infarction in rat.
Rivard AL, et al. Am J Chin Med. 2007;35(2):279-95. PMID: 17436368.

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Keywords: Tauroursodeoxycholic acid, TUDCA supplier, inhibitors

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