Tauroursodeoxycholic acid (TUDCA) is an ambiphilic bile acid. TUDCA is the taurine conjugate form of ursodeoxycholic acid (UDCA). TUDCA has been used in ancient Asian pharmacopoeias for its supposed beneficial effects. Ongoing research is finding TUDCA has diminishing apoptotic effects, helping with cardiac function, Huntington's disease, Parkinson's Disease, and stroke.
J Ethnopharmacol. 2022 October 5;296:115519.
Lycium barbarum L. and Salvia miltiorrhiza Bunge protect retinal pigment epithelial cells through endoplasmic reticulum stress
Tauroursodeoxycholic acid (Ursodoxicoltaurine) purchased from AbMole
Biomed Pharmacother. 2018 Jul 20;106:1271-1281.
Tauroursodeoxycholic acid alleviates hepatic ischemia reperfusion injury by suppressing the function of Kupffer cells in mice.
Tauroursodeoxycholic acid (Ursodoxicoltaurine) purchased from AbMole
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Source | Biomedicine & Pharmacotherapy (2018). Figure 7. TUDCA (AbMole BioScience Ltd.) |
| Method | injected intraperitoneally | |
| Cell Lines | mice | |
| Concentrations | 400 mg/kg | |
| Incubation Time | 3 d | |
| Results | Following treatment with TUDCA, the levels of all the proinflammatory cytokines were significantly decreased. |
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Source | Biomedicine & Pharmacotherapy (2018). Figure 6. TUDCA (AbMole BioScience Ltd.) |
| Method | injected intraperitoneally | |
| Cell Lines | mice | |
| Concentrations | 400 mg/kg | |
| Incubation Time | 3 d | |
| Results | In contrast, following treatment with TUDCA, few TUNEL positive hepatic cells were observed compared with those in the I/R group |
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Source | Biomedicine & Pharmacotherapy (2018). Figure 5. TUDCA (AbMole BioScience Ltd.) |
| Method | injected intraperitoneally | |
| Cell Lines | mice | |
| Concentrations | 400 mg/kg | |
| Incubation Time | 3 h, 6 h, and 24 h | |
| Results | However, following treatment with TUDCA, all the above mentioned markers were significantly decreased in the I/R + TUDCA group |
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Source | Biomedicine & Pharmacotherapy (2018). Figure 4. TUDCA (AbMole BioScience Ltd.) |
| Method | cell viability assay | |
| Cell Lines | KCs | |
| Concentrations | 25 μM | |
| Incubation Time | 96 h | |
| Results | These results demonstrated that TUDCA effectively alleviates the apoptosis of AML cells. |
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Source | Biomedicine & Pharmacotherapy (2018). Figure 3. TUDCA (AbMole BioScience Ltd.) |
| Method | immunofluorescence staining | |
| Cell Lines | KCs | |
| Concentrations | 25 uM | |
| Incubation Time | 24 h | |
| Results | The results of immunofluorescence staining showed that, following treatment with an increased concentration of TUDCA, the intensity of fluorescence in the nucleus of KCs was significantly decreased. |
 |
Source | Biomedicine & Pharmacotherapy (2018). Figure 2. TUDCA (AbMole BioScience Ltd.) |
| Method | RT-PCR | |
| Cell Lines | KCs | |
| Concentrations | 0 μM, 25 μM, 50 μM, and 100 μM | |
| Incubation Time | 24 h | |
| Results | Moreover, following treatment with different concentrations of TUDCA, the level of the abovementioned proinflammatory cytokines presented a dose-dependent decrease |
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Source | Biomedicine & Pharmacotherapy (2018). Figure 1. TUDCA (AbMole BioScience Ltd.) |
| Method | cell viability assay | |
| Cell Lines | KCs | |
| Concentrations | 0 μM, 25 μM, 50 μM, and 100 μM | |
| Incubation Time | 96 h | |
| Results | The effects of different concentrations of TUDCA on the cell viability of KCs were determined by the MTT assay |
| Molecular Weight | 499.7 |
| Formula | C26H45NO6S |
| CAS Number | 14605-22-2 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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