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Tauroursodeoxycholic acid

Cat. No. M5158
Tauroursodeoxycholic acid Structure
Synonym:

TUDCA

Size Price Availability Quantity
100mg USD 80 In stock
500mg USD 160 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Tauroursodeoxycholic acid (TUDCA) is an ambiphilic bile acid. TUDCA is the taurine conjugate form of ursodeoxycholic acid (UDCA). TUDCA has been used in ancient Asian pharmacopoeias for its supposed beneficial effects. Ongoing research is finding TUDCA has diminishing apoptotic effects, helping with cardiac function, Huntington's disease, Parkinson's Disease, and stroke.

Product Citations
Customer Product Validations & Biological Datas
Source Biomedicine & Pharmacotherapy (2018). Figure 7. TUDCA (AbMole BioScience Ltd.)
Method injected intraperitoneally
Cell Lines mice
Concentrations 400 mg/kg
Incubation Time 3 d
Results Following treatment with TUDCA, the levels of all the proinflammatory cytokines were significantly decreased.
Source Biomedicine & Pharmacotherapy (2018). Figure 6. TUDCA (AbMole BioScience Ltd.)
Method injected intraperitoneally
Cell Lines mice
Concentrations 400 mg/kg
Incubation Time 3 d
Results In contrast, following treatment with TUDCA, few TUNEL positive hepatic cells were observed compared with those in the I/R group
Source Biomedicine & Pharmacotherapy (2018). Figure 5. TUDCA (AbMole BioScience Ltd.)
Method injected intraperitoneally
Cell Lines mice
Concentrations 400 mg/kg
Incubation Time 3 h, 6 h, and 24 h
Results However, following treatment with TUDCA, all the above mentioned markers were significantly decreased in the I/R + TUDCA group
Source Biomedicine & Pharmacotherapy (2018). Figure 4. TUDCA (AbMole BioScience Ltd.)
Method cell viability assay
Cell Lines KCs
Concentrations 25 μM
Incubation Time 96 h
Results These results demonstrated that TUDCA effectively alleviates the apoptosis of AML cells.
Source Biomedicine & Pharmacotherapy (2018). Figure 3. TUDCA (AbMole BioScience Ltd.)
Method immunofluorescence staining
Cell Lines KCs
Concentrations 25 uM
Incubation Time 24 h
Results The results of immunofluorescence staining showed that, following treatment with an increased concentration of TUDCA, the intensity of fluorescence in the nucleus of KCs was significantly decreased.
Source Biomedicine & Pharmacotherapy (2018). Figure 2. TUDCA (AbMole BioScience Ltd.)
Method RT-PCR
Cell Lines KCs
Concentrations 0 μM, 25 μM, 50 μM, and 100 μM
Incubation Time 24 h
Results Moreover, following treatment with different concentrations of TUDCA, the level of the abovementioned proinflammatory cytokines presented a dose-dependent decrease
Source Biomedicine & Pharmacotherapy (2018). Figure 1. TUDCA (AbMole BioScience Ltd.)
Method cell viability assay
Cell Lines KCs
Concentrations 0 μM, 25 μM, 50 μM, and 100 μM
Incubation Time 96 h
Results The effects of different concentrations of TUDCA on the cell viability of KCs were determined by the MTT assay
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 499.7
Formula C26H45NO6S
CAS Number 14605-22-2
Purity >98%
Solubility
Storage at -20°C
References

Administration of tauroursodeoxycholic acid (TUDCA) reduces apoptosis following myocardial infarction in rat.
Rivard AL, et al. Am J Chin Med. 2007;35(2):279-95. PMID: 17436368.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Tauroursodeoxycholic acid, TUDCA supplier, ERK, inhibitors

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