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Astragaloside IV

Cat. No. M2149
Astragaloside IV Structure
Synonym:

Astragaloside A

Size Price Availability Quantity
10mg USD 160 In stock
50mg USD 320 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Astragaloside IV (synonyms Astragaloside A) is a pure small molecular compound isolated from Radix Astragali and is commonly used in the treatment of degenerative bone diseases such as osteoporosis. Administration of astragaloside IV reduced blood pressure and triglyceride levels in fructose-fed rats and high dose of astragaloside IV also improved glucose tolerance and endothelium-dependent vasorelaxation. The astragaloside IV-induced improvement in vasorelaxation was associated with increased levels of aortic NOx and cGMP and was abrogated by blockade of nitric oxide synthase with NG-nitro-l-arginine methyl ester (l-NAME). Astragaloside IV (Astragaloside A) has a potent preventive action on myocardial fibrosis in CVB3-induced dilated cardiomyopathy that might be due to downregulation of TGF-β1-Smad signaling.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 784.97
Formula C41H68O14
CAS Number 83207-58-3
Purity >99%
Solubility DMSO
Storage at -20°C
References

Astragaloside IV improves metabolic syndrome and endothelium dysfunction in fructose-fed rats.
Zhang N, et al. Molecules. 2011 May 10;16(5):3896-907. PMID: 21555978.

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Keywords: Astragaloside IV, Astragaloside A supplier, TGF-beta, inhibitors

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