| Cat.No. | Name | Information |
|---|---|---|
| M2084 | SCH772984 | SCH772984 is a novel and selective inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively. |
| M5158 | Tauroursodeoxycholic acid (Ursodoxicoltaurine) | Tauroursodeoxycholic acid (Ursodoxicoltaurine) is an endoplasmic reticulum stress inhibitor. It can significantly reduce the expression of apoptotic molecules such as caspase-3 and caspase-12. Tauroursodeoxycholate also suppresses ERK. It is a taurine conjugate of usodeoxycholic acid. |
| M4037 | Astragaloside IV | Astragaloside IV is a bioactive saponin first isolated from the dried plant roots of the genus Astragalus, which is used in traditional Chinese medicine. It has various effect on the cardiovascular, immune, digestive, and nervous systems. |
| M20330 | WAY-340245 | WAY-340245 is a ERK inhibitor. |
| M19387 | Deltonin | Deltonin, a steroidal saponin, isolated from Dioscorea zingiberensis, with antitumor activity; Deltonin inhibits ERK1/2 and AKT activation. |
| M14155 | Ulixertinib hydrochloride | Ulixertinib hydrochloride (BVD-523 hydrochloride) is a potent, orally active, highly selective, ATP-competitive and reversible covalent inhibitor of ERK1/2 kinases, with an IC50 of <0.3 nM against ERK2. |
| M14153 | Ravoxertinib hydrochloride | Ravoxertinib hydrochloride (GDC-0994 hydrochloride) is an orally bioavailable inhibitor selective for ERK kinase activity with IC50 of 6.1 nM and 3.1 nM for ERK1 and ERK2, respectively. |
| M14152 | ERK1/2 inhibitor 1 | ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively. |
| M14151 | CC-90003 | CC-90003 is an irreversible and selective inhibitor of ERK 1/2 with antitumor activity. |
| M14150 | AX-15836 | AX-15836 is a potent and selective ERK5 inhibitor with an IC50 of 8 nM. |
| M11021 | (rel)-AR234960 | (rel)-AR234960 is the relatively active configuration of AR234960. AR234960 is a non-peptide MAS (a G protein coupling receptor) agonist that upregulates CTGF mRNA and protein levels through the ERK1/2 signaling pathway in HEK293-MAS cells and adult myocardial fibroblasts. |
| M10880 | Rineterkib hydrochloride | Rineterkib hydrochloride (compound B) is an orally active inhibitor of ERK1/2 that exerts an antiproliferative effect by activating mutations in the MAPK pathway. This activity is particularly associated with KRAS-mutant non-small cell lung cancer, BRAF-mutant non-small cell lung cancer, KRAS-mutant pancreatic cancer, KRAS-mutant colon cancer, and KRAS mutant ovarian cancer. Rineterkib hydrochloride can also inhibit RAF. |
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