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CC-90003

Cat. No. M14151
CC-90003 Structure
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Biological Activity

CC-90003 is an irreversible and selective inhibitor of ERK 1/2 with antitumor activity.

Chemical Information
Molecular Weight 458.44
CAS Number 1621999-82-3
Solubility (25°C) DMSO ≥ 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Lei Mi, et al. Remote ischemic post‑conditioning alleviates ischemia/reperfusion‑induced intestinal injury via the ERK signaling pathway‑mediated RAGE/HMGB axis

[2] David G Belair, et al. Investigation Into the Role of ERK in Tyrosine Kinase Inhibitor-Induced Neuropathy

[3] Robert Roskoski Jr. Targeting ERK1/2 protein-serine/threonine kinases in human cancers

[4] Ida Aronchik, et al. Efficacy of a Covalent ERK1/2 Inhibitor, CC-90003, in KRAS-Mutant Cancer Models Reveals Novel Mechanisms of Response and Resistance

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  Catalog
Abmole Inhibitor Catalog




Keywords: CC-90003 supplier, ERK, inhibitors, activators


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