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Tauroursodeoxycholate dihydrate

Cat. No. M11050
Tauroursodeoxycholate dihydrate Structure
Synonym:

Tauroursodeoxycholic acid dihydrate

Size Price Availability Quantity
50mg USD 55  USD55 In stock
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Quality Control & Documentation
Biological Activity

Tauroursodeoxycholate (Tauroursodeoxycholic acid; TDUCA) dihydrate is an endoplasmic reticulum stress inhibitor. Tauroursodeoxycholate significantly reduces the expression of apoptotic molecules such as caspase-3 and caspase-12. Tauroursodeoxycholate also suppresses ERK.

Chemical Information
Molecular Weight 534.72622
Formula C26H49NO8S
CAS Number 117609-50-4
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Gautam K Gandhi, et al. ASN Neuro. Hyperglycaemia and diabetes impair gap junctional communication among astrocytes

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Keywords: Tauroursodeoxycholate dihydrate, Tauroursodeoxycholic acid dihydrate supplier, ERK, inhibitors, activators


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