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Abmole Inhibitor Catalog 2017

COX Cyclooxygenase


Cat.No.  Name Information
M10099 CAY10404 CAY10404 is one of the most selective inhibitors of COX-2 (IC50 = 1 nM) over COX-1.
M9682 TFAP TFAP is a selective cyclooxygenase-1 (COX-1) inhibitor with IC50 of 0.8 μM.
M7051 NS 398 NS 398 is a cyclooxygenase-2 (COX-2) inhibitor.
M6057 Vitamin E Vitamin E is a fat-soluble vitamin with potent antioxidant properties. It is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription.
M5996 Tenoxicam Tenoxicam is a good HO. radicals scavenger with an IC50 of 56.7 μM.
M5985 Suprofen Suprofen is a dual COX-1/COX-2 inhibitor, used as a non-steroidal anti-inflammatory analgesic and antipyretic.
M5945 Salicylic acid Salicylic acid is a beta hydroxy acid that occurs as a natural compound in plants which is an inhibitor of ethylene biosynthesis and cyclooxygenase activity.
M5907 Propyphenazone Propyphenazone is a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors.
M5893 Pranoprofen Pranoprofen is a non-steroidal COX inhibitor, used as an anti-inflammatory drug in ophthalmology.
M5874 Phenacetin Phenacetin is a non-opioid analgesic without anti-inflammatory properties.
M5859 Parecoxib Sodium Parecoxib is a potent and selective COX-2 inhibitor.
M5858 Parecoxib Parecoxib is a selective COX2 inhibitor.
M5814 Niflumic acid Niflumic acid is an inhibitor of cyclooxygenase-2 used for joint and muscular pain.
M5755 Loxoprofen Loxoprofen is a non-steroidal anti-inflammatory drug in the propionic acid derivatives group.
M5703 Iguratimod Iguratimod(T-614) is a selective inhibitor of cyclo-oxygenase-2 (COX-2), and inhibits the production of interleukin-1 (IL-1), IL-6, IL-8 and tumour necrosis factor.
M5658 Flurbiprofen Flurbiprofen is a member of the phenylalkanoic acid derivative family of non-steroidal anti-inflammatory drugs (NSAIDs).
M5655 Flunixin Meglumin Flunixin Meglumin is a potent inhibitor of the enzyme cyclooxygenase used as analgesic agent with anti-inflammatory and antipyretic activity.
M5639 Fenbufen Fenbufen is an orally active phenylalkanoic derivative with anti-inflammatory, analgesic and antipyretic activity. It is a non-steroidal anti-inflammatory drug.
M5634 Etodolac Etodolac is a nonsteroidal anti-inflammatory drug (NSAID) and a COX inhibitor, used for the treatment of inflammation and pain.
M5574 Diflunisal Diflunisal is a difluorophenyl derivate of salicylic acid and a nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic and anti-inflammatory properties. The mechanism of action of diflunisal is as a Cyclooxygenase Inhibitor.
M5572 Diclofenac Diclofenac (diclofenac) is a COX inhibitor and has an IC50 of 60 and 220 nM for sheep COX-1 and -2, respectively.
M5426 Aspirin Aspirin is a salicylate, and irreversible COX1 and COX2 inhibitor, used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication.
M5381 Acemetacin Acemetacin is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.
M5379 Aceclofenac Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) analog of Diclofenac.
M5361 2-Ethoxybenzamide 2-Ethoxybenzamide is a common analgesic and anti-inflammatory drug that is used for the relief of fever, headaches, and other minor aches and pains.
M5352 (R)-(-)-Ibuprofen (R)-Ibuprofen, a nonsteroidal anti-inflammatory, is the less active enantiomer of ibuprofen, an inhibitor of Cox-1 and Cox-2.
M5351 (+/-)-Sulfinpyrazone Sulfinpyrazone is one of the most studied platelet COX inhibitors, also a uricosuric agent that competitively inhibits uric acid reabsorption in kidney proximal tubules.
M5185 Xanthohumol Xanthohumol
M4667 Homoori-entin Homoori-entin
M4437 Rutaecarpine Rutaecarpine is a delayed rectifier K+ channel blocker, inhibits platelet aggregation.
M4207 EC (-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 3.2 μM.
M4088 Ginsenoside Compound-K Ginsenoside Compound-K is a bacterial metabolite of G-Rb1, exhibits anti-inflammatory effects by reducing iNOS and COX-2.
M3809 Isofraxidin Isofraxidin is an anti-bacterial, anti-oxidant, and anti-inflammatory agent, it acts by reducing the levels of tumor necrosis factor-a (TNF-a), interleukin-6 (IL-6), and prostaglandin E2 (PGE2), inhibiting cyclooxygenase-2 (COX-2) protein expression.
M3614 FK-3311 FK 3311 is a selective inhibitor of COX-2; antiinflammatory agent.
M3608 Naproxen Naproxen is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively.
M3471 Ketorolac Ketorolac (Ketorolac tromethamine) is a non-selective COX inhibitor of COX-1 and COX-2 with IC50 of 1.23 μM and 3.50 μM, respectively.
M3466 Indomethacin Indomethacin is a non-steroidal anti-inflammatory compound commonly used to reduce fever, pain, stiffness, and swelling.
M3439 Licofelone Licofelone is a dual COX/LOX inhibitor being considered as a treatment for osteoarthritis.
M3429 Piroxicam Piroxicam is a non-selective COX inhibitor with an IC50 of 6 mM.
M3420 Diclofenac Sodium Diclofenac Sodium is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively.
M3398 Nimesulide Nimesulide is a relatively COX-2 selective inhibitor with IC50 of 26 μM.
M3391 Ketoprofen Ketoprofen is a non-selective NSAID with IC50 of 0.5 μM and 2.33 μM for human recombinant COX-1 and COX-2, respectively.
M3362 Tolfenamic Acid Tolfenamic Acid is a COX-2 inhibitor with IC50 of 0.2 μM.
M3360 Zaltoprofen Zaltoprofen is an inhibitor of Cox-1 and Cox-2 for treatment of arthritis.
M3359 Ibuprofen Ibuprofen (Dolgesic) is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively.
M3308 Asaraldehyde Asaraldehyde is a natural COX-2 inhibitor, exhibiting 17-fold selectivity over COX-1.
M3301 Acetaminophen Acetaminophen is a COX inhibitor for COX-1 and COX-2 with IC50 of 113.7 μM and 25.8 μM, respectively. *The compound is unstable in solutions, freshly prepared is recommended
M3264 Pravadoline Pravadoline (WIN 48098) is a cyclooxygesase inhibitor and inhibits prostaglandin synthesis with IC50 of 4.9 μM, also a cannabinoid agonist.
M3203 Lornoxicam Lornoxicam is a COX-1 and COX-2 inhibitor with IC50 of 5 nM and 8 nM, respectively.

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