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Abmole Inhibitor Catalog 2017

COX Cyclooxygenase


Cat.No.  Name Information
M5426 Aspirin Aspirin is a salicylate, and irreversible COX1 and COX2 inhibitor, used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication.
M5381 Acemetacin Acemetacin is a non-steroidal anti-inflammatory drug and a glycolic acid ester of indometacin that is a cyclooxygenase inhibitor.
M5379 Aceclofenac Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) analog of Diclofenac.
M5361 2-Ethoxybenzamide 2-Ethoxybenzamide is a common analgesic and anti-inflammatory drug that is used for the relief of fever, headaches, and other minor aches and pains.
M5352 (R)-(-)-Ibuprofen (R)-Ibuprofen, a nonsteroidal anti-inflammatory, is the less active enantiomer of ibuprofen, an inhibitor of Cox-1 and Cox-2.
M5351 (+/-)-Sulfinpyrazone Sulfinpyrazone is one of the most studied platelet COX inhibitors, also a uricosuric agent that competitively inhibits uric acid reabsorption in kidney proximal tubules.
M3914 Gallic acid Gallic acid is an antiinflammatory and Cox inhibitor substance found in plants and has been shown to Induce apoptosis in human lung cancer cells.
M3614 FK-3311 FK 3311 is a selective inhibitor of COX-2; antiinflammatory agent.
M3608 Naproxen Naproxen is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively.
M3471 Ketorolac Ketorolac (Ketorolac tromethamine) is a non-selective COX inhibitor of COX-1 and COX-2 with IC50 of 1.23 μM and 3.50 μM, respectively.
M3439 Licofelone Licofelone is a dual COX/LOX inhibitor being considered as a treatment for osteoarthritis.
M3429 Piroxicam Piroxicam is a non-selective COX inhibitor with an IC50 of 6 mM.
M3420 Diclofenac Sodium Diclofenac Sodium is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively.
M3398 Nimesulide Nimesulide is a relatively COX-2 selective inhibitor with IC50 of 26 μM.
M3391 Ketoprofen Ketoprofen is a non-selective NSAID with IC50 of 0.5 μM and 2.33 μM for human recombinant COX-1 and COX-2, respectively.
M3362 Tolfenamic Acid Tolfenamic Acid is a COX-2 inhibitor with IC50 of 0.2 μM.
M3360 Zaltoprofen Zaltoprofen is an inhibitor of Cox-1 and Cox-2 for treatment of arthritis.
M3359 Ibuprofen Ibuprofen (Dolgesic) is an anti-inflammatory inhibitor targeting COX-1 and COX-2 with IC50 of 13 μM and 370 μM, respectively.
M3308 Asaraldehyde Asaraldehyde is a natural COX-2 inhibitor, exhibiting 17-fold selectivity over COX-1.
M3301 Acetaminophen Acetaminophen is a COX inhibitor for COX-1 and COX-2 with IC50 of 113.7 μM and 25.8 μM, respectively.
M3264 Pravadoline Pravadoline (WIN 48098) is a cyclooxygesase inhibitor and inhibits prostaglandin synthesis with IC50 of 4.9 μM, also a cannabinoid agonist.
M3203 Lornoxicam Lornoxicam is a COX-1 and COX-2 inhibitor with IC50 of 5 nM and 8 nM, respectively.
M3148 ATB 346 ATB-346 is a novel hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity.
M3112 Valdecoxib Valdecoxib is a potent and selective inhibitor of COX-2 with IC50 of 5 nM.
M3089 Triflusal Triflusal irreversibly inhibits the production of thromboxane-B2 in platelets by acetylating cycloxygenase-1.
M2984 Rofecoxib Rofecoxib is a COX-2 inhibitor with IC50 of 18 nM.
M2871 Nabumetone Nabumetone is a non-steroidal anti-inflammatory compound and its active metabolite inhibits the COX.
M2835 Mefenamic Acid Mefenamic Acid is a competitive inhibitor of COX-1 and COX-2.
M2824 Lumiracoxib Lumiracoxib is a novel, selective COX-2 inhibitor with IC50 and Ki of 0.14 μM and 0.06 μM, exhibits 515-fold selectivity over COX-1.
M2817 Meclofenamate sodium Meclofenamate sodium is a dual COX-1/COX-2 inhibitor with IC50 of 40 nM and 50 nM, respectively.
M2478 Bufexamac Bufexamac is a COX inhibitor for IFN-α release with EC50 of 8.9 μM.
M2392 Ampiroxicam Ampiroxicam is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory compound.
M2233 Nepafenac Nepafenac is an analgesic selective inhibitor of COX-2.
M1965 Celecoxib Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor (IC50 values are 15 and 0.04 μM for COX-1 and COX-2 respectively).
M1830 Firocoxib Firocoxib is a selective COX-2 inhibitor exhibiting high selectivity to inhibit COX-2.

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