Free shipping on all orders over $ 500


Cat. No. M3264
Pravadoline Structure

WIN 48098

Size Price Availability Quantity
50mg USD 180 In stock
200mg USD 600 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Pravadoline (WIN 48098) is an antiinflammatory and analgesic compound with an IC50 of 4.9 uM for inhibition of the synthesis of prostaglandins (PGs) in mouse brain. Pravadoline (WIN 48098) is related in structure to non-steroidal antinflammtory agents such as indometacin. Pravadoline (WIN 48098) was developed in the 1980s as a new antiinflammatory and prostaglandin synthesis inhibitor, acting through inhibition of the enzyme cyclooxygenase (COX).

Product Citations
Customer Product Validations & Biological Datas
Source Org Lett (2016). Scheme 1. WIN 48098 (Abmole Bioscience Inc.)
Method Short Synthesis
Cell Lines
Incubation Time
Results This new synthetic method provides a short synthesis of pravadoline 7a (WIN 48098) that acts as a potent antiinflammatory and analgesic drug (IC50 4.9 μM, Ki 2511 nM at CB1).
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 378.46
Formula C23H26N2O3
CAS Number 92623-83-1
Purity >98%
Solubility DMSO
Storage at -20°C
Related COX Products
NS 398

NS 398 is a cyclooxygenase-2 (COX-2) inhibitor.

Vitamin E

Vitamin E is a fat-soluble vitamin with potent antioxidant properties. It is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription.


Tenoxicam is a good HO. radicals scavenger with an IC50 of 56.7 μM.


Suprofen is a dual COX-1/COX-2 inhibitor, used as a non-steroidal anti-inflammatory analgesic and antipyretic.

Salicylic acid

Salicylic acid is a beta hydroxy acid that occurs as a natural compound in plants which is an inhibitor of ethylene biosynthesis and cyclooxygenase activity.

Abmole Inhibitor Catalog 2017

Keywords: Pravadoline, WIN 48098 supplier, COX, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2017 AbMole BioScience. All Rights Reserved.