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Lumiracoxib

Cat. No. M2824
Lumiracoxib Structure
Synonym:

COX-189

Size Price Availability Quantity
5mg USD 50  USD50 In stock
10mg USD 70  USD70 In stock
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Quality Control & Documentation
Biological Activity

Lumiracoxib is a novel, selective COX-2 inhibitor with IC50 and Ki of 0.14 μM and 0.06 μM, exhibits 515-fold selectivity over COX-1.

Product Citations
Chemical Information
Molecular Weight 293.72
Formula C15H13ClFNO2
CAS Number 220991-20-8
Solubility (25°C) DMSO 40 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ricardo Carvalho Lopes Silva, et al. Lumiracoxib for acute postoperative dental pain: a systematic review of randomized clinical trials

[2] Y-F Chen, et al. Cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs (etodolac, meloxicam, celecoxib, rofecoxib, etoricoxib, valdecoxib and lumiracoxib) for osteoarthritis and rheumatoid arthritis: a systematic review and economic evaluation

[3] Bernard Bannwarth, et al. Lumiracoxib in the management of osteoarthritis and acute pain

[4] Asokumar Buvanendran, et al. Lumiracoxib

[5] Katherine A Lyseng-Williamson, et al. Lumiracoxib

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  Catalog
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Keywords: Lumiracoxib, COX-189 supplier, COX, inhibitors, activators


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