| Cat.No. | Name | Information |
|---|---|---|
| M2497 | Cathepsin Inhibitor 1 | Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively. |
| M9353 | N-Ethylmaleimide | N-Ethylmaleimide (NEM) is a cysteine protease inhibitor. |
| M3636 | Leupeptin hemisulfate | Leupeptin hemisulfate hemisulfate is the reversible inhibitor of lysosomal serine and cysteine proteinases; Leupeptin; inhibition of cathepsin B(Ki=6 nM), calpain(Ki=10 nM), trypsin (Ki=35 nM), plasmin (Ki=3.4 μM) and kallikrein (Ki=19 μM) had no effect on chymotrypsin, elastase, renin, or pepsin. |
| M1985 | Odanacatib | Odanacatib (MK-0822) is a potent and reversible covalent inhibitor of CathepsinK (CatK) with an IC50 of 0.2 nM/1 nM for human/rabbit cathepsin B, L, and S and is highly selective. |
| M52651 | Z-FG-NHO-Bz | Z-FG-NHO-Bz is a selective cathepsin inhibitor. |
| M52650 | Z-DEVD-CMK | Z-DEVD-CMK is an irreversible inhibitor of most of the cathepsins in vitro. |
| M52649 | RKLLW-NH2 | RKLLW-NH2 is a Cathepsin L inhibitor. |
| M52648 | Z-FF-FMK | Z-FF-FMK is a selective cathepsin-L inhibitor. |
| M42307 | Z-Phe-Arg-pNA | Z-Phe-Arg-pNA is a substrate of Cathepsin L. |
| M42306 | LN5P45 | LN5P45 is an OTUB2 inhibitor (IC50: 2.3 μM). |
| M42305 | TSC25 | TSC25 is a potent cruzipain (CZP) inhibitor, with an IC50 of 3.34 nM and a pIC50 of 8.48. |
| M42304 | Ac-VLPE-FMK | Ac-VLPE-FMK, a tetrapeptidyl mono-fluoromethyl ketone (m-FMK), is a Cat-B and Cat-L inhibitor. |
| M42302 | Cathepsin C-IN-6 | Cathepsin C-IN-6 is a E-64c-hydrazideas based inhibitor of cathepsin C with anti-inflammatory activity. |
| M42301 | JNJ 10329670 | JNJ 10329670 is a potent and selective noncovalent cathepsin S inhibitor with a Ki value of 34 nM for human cathepsin S. |
| M40618 | MIV-711 | MIV-711 is a potent, selective tissue proteinase K (CTSK) inhibitor for osteoarthritis (OA)-related studies. |
| M30755 | ONO-5334 | ONO-5334 is a potent, selective and orally active cathepsin K inhibitor with Ki values of 0.10 nM, 0.049 nM and 0.85 nM for human, rabbit and rat cathepsin K, respectively. ONO 5334 is an effective antiviral compound against SAR-COV-2 virus activity with an EC50 value of 500 nM. ONO-5334 has the potential for the study of osteoporosis and COVID-19 disease. |
| M30349 | L-873724 | L-873724 is a potent, orally bioavailable, selective and reversible[2] non-basic cathepsin K inhibitor, with IC50s of 0.2, 178, 264, and 5239 nM for cathepsin K, cathepsin S, cathepsin L, cathepsin B, respectively. L-873724 also exhibits an IC50 of 0.5 nM for rabbit cathepsin K. L-873724 inhibits bone resorption. |
| M29991 | Relacatib | Relacatib (SB-462795) is a novel, potent, and orally active inhibitor of human cathepsins K, L, and V with Ki values of 41 pM, 68 pM, and 53 pM, respectively. Relacatib inhibits endogenous cathepsin K in situ in human osteoclasts and human osteoclast-mediated bone resorption with IC50 values of 45 nM and 70 nM, respectively. Relacatib inhibits bone resorption in vitro in human tissue as well as in cynomolgus monkeys in vivo. |
| M29733 | JPM-OEt | JPM-OEt is a broad spectrum cysteine cathepsin inhibitor. JPM-OEt binds covalently in the active site, and irreversibly inhibits the cysteine cathepsin family. Antitumor activity. |
| M29515 | K777 | K777 is a potent, orally active and irreversible cysteine protease inhibitor. K777 is also a potent CYP3A4 inhibitor with an IC50 of 60 nM and a selective CCR4 antagonist featuring the potent chemotaxis inhibition. K777 irreversibly inhibits Cruzain, the major cysteine protease of Trypansoma cruzi, and cathepsins B and L. K777 is a broad-spectrum antiviral by targeting cathepsin-mediated cell entry. K777 inhibits SARS-CoV and EBOV pseudovirus entry with IC50 values of 0.68 nM and 0.87 nM, respectively. |
| M28683 | GSK2793660 hydrochloride | GSK2793660 hydrochloride is an orally active, irreversible cathepsin C (CTSC) inhibitor for bronchodilation studies. |
| M28225 | MIV-247 | MIV-247 is a selective cathepsin S inhibitor with Kis of 2.1, 4.2 and 7.5 nM for human, mouse and cynomolgus monkey cathepsin S, respectively. |
| M28042 | Petesicatib | Petesicatib is a cathepsin S inhibitor, used in research of immune diseases. |
| M27825 | KGP94 | KGP94 is a selective inhibitor of cathepsin L with an IC50 of 189 nM. KGP94 inhibits migration and invasion of metastatic carcinoma and shows low cytotoxicity (GI50=26.9 µM) against various human cell lines. |
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