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MIV-711

Cat. No. M40618
MIV-711 Structure
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Biological Activity

MIV-711 is a potent, selective tissue proteinase K (CTSK) inhibitor for osteoarthritis (OA)-related studies.

Chemical Information
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Asger Reinstrup Bihlet et al. Clin Exp Rheumatol. Symptomatic and structural benefit of cathepsin K inhibition by MIV-711 in a subgroup with unilateral pain: post-hoc analysis of a randomised phase 2a clinical trial

[2] Yaongamphi Vashum et al. Mol Biol Rep. Inhibitory effect of cathepsin K inhibitor (ODN-MK-0822) on invasion, migration and adhesion of human breast cancer cells in vitro

[3] Philip G Conaghan et al. Ann Intern Med. Disease-Modifying Effects of a Novel Cathepsin K Inhibitor in Osteoarthritis: A Randomized Controlled Trial

[4] Erik Lindström et al. J Transl Med. Nonclinical and clinical pharmacological characterization of the potent and selective cathepsin K inhibitor MIV-711

[5] Erik Lindström et al. J Transl Med. The selective cathepsin K inhibitor MIV-711 attenuates joint pathology in experimental animal models of osteoarthritis

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Keywords: MIV-711 supplier, Cathepsin, inhibitors, activators

 
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