Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||DMSO 70 mg/mL|
|Source||Oncotarget (2017). Figure 3. Cathepsin inhibitor 1 (AbMole BioScience, Shanghai, China)|
|Cell Lines||SGC-7901 and GES-1 cells|
|Incubation Time||2 h|
|Results||As shown in Figure 3E, the cathepsin inhibitor 1, an inhibitor of Cathepsin L, Cathepsin L2, Cathepsin S, Cathepsin K and Cathepsin B, could not reduce hispidin-induced cell death. This indicates that cathepsins were not the real driver of the process.|
Oncotarget. 2017 Apr 18;8(16):26992-27006.
Hispidin induces autophagic and necrotic death in SGC-7901 gastric cancer cells through lysosomal membrane permeabilization by inhibiting tubulin polymerization
Cathepsin Inhibitor 1 purchased from AbMole
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