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N-Ethylmaleimide

Cat. No. M9353
N-Ethylmaleimide Structure
Synonym:

NEM

Size Price Availability Quantity
10mg USD 47  USD47 In stock
50mg USD 95  USD95 In stock
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Quality Control & Documentation
Biological Activity

N-Ethylmaleimide (NEM) is a cysteine protease inhibitor. N-ethylmaleimide specific inhibits phosphate transport in mitochondria.

Product Citations
Chemical Information
Molecular Weight 125.13
Formula C6H7NO2
CAS Number 128-53-0
Solubility (25°C) DMSO ≥ 25 mg/mL
Storage 4°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Wu KH, et al. J Biol Chem. Cys32 and His105 are the critical residues for the calcium-dependent cysteine proteolytic activity of CvaB, an ATP-binding cassette transporter.

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Keywords: N-Ethylmaleimide, NEM supplier, Cathepsin, inhibitors, activators


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