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N-Ethylmaleimide

Cat. No. M9353
N-Ethylmaleimide Structure
Synonym:

NEM

Size Price Availability Quantity
10mg USD 47 In stock
50mg USD 95 In stock
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Quality Control
Biological Activity

N-Ethylmaleimide (NEM) is a cysteine protease inhibitor. N-ethylmaleimide specific inhibits phosphate transport in mitochondria.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 125.13
Formula C6H7NO2
CAS Number 128-53-0
Purity >98%
Solubility DMSO ≥ 25 mg/mL
Storage 4°C, protect from light, dry, sealed
References

Cys32 and His105 are the critical residues for the calcium-dependent cysteine proteolytic activity of CvaB, an ATP-binding cassette transporter.
Wu KH, et al. J Biol Chem. 2004 Jan 9;279(2):901-9. PMID: 14570918.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: N-Ethylmaleimide, NEM supplier, Cathepsin, inhibitors

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