N-Ethylmaleimide (NEM) is a cysteine protease inhibitor. N-ethylmaleimide specific inhibits phosphate transport in mitochondria.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||DMSO ≥ 25 mg/mL|
|Storage||4°C, protect from light, dry, sealed|
Cys32 and His105 are the critical residues for the calcium-dependent cysteine proteolytic activity of CvaB, an ATP-binding cassette transporter.
Wu KH, et al. J Biol Chem. 2004 Jan 9;279(2):901-9. PMID: 14570918.
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