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Leupeptin hemisulfate

Cat. No. M3636
Leupeptin hemisulfate Structure
Size Price Availability Quantity
5mg USD 57  USD57 In stock
10mg USD 80  USD80 In stock
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Biological Activity

Leupeptin hemisulfate hemisulfate is the reversible inhibitor of lysosomal serine and cysteine proteinases; Leupeptin; inhibition of cathepsin B(Ki=6 nM), calpain(Ki=10 nM), trypsin (Ki=35 nM), plasmin (Ki=3.4 μM) and kallikrein (Ki=19 μM) had no effect on chymotrypsin, elastase, renin, or pepsin.

Product Citations
Chemical Information
Molecular Weight 475.59
Formula C20H38N6O4.½H2SO4
CAS Number 103476-89-7
Solubility (25°C) Water 10 mg/mL
DMSO 60 mg/mL
Storage -20°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Marina Nagler, et al. Cannabinoid receptor 2 expression modulates Gβ(1)γ(2) protein interaction with the activator of G protein signalling 2/dynein light chain protein Tctex-1

[2] T R Ganapathi, et al. Analysis of the limitations of hepatitis B surface antigen expression in soybean cell suspension cultures

[3] L C Morejohn, et al. Inhibition of plant cell proteolytic activities that degrade tubulin

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