About 19 results found for searched term "Cholesterol" (0.249 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2516 | Cholesterol | Estrogen Receptor |
| Cholesterol is a major sterol in mammals, accounting for 20-25% of the structural components of the plasma membrane, and plays an important role in characterizing membrane fluidity and permeability, as well as the function of transporter and signaling proteins. In addition, Cholesterol is an endogenous estrogen-related receptor alpha (ERRα) agonist. | ||
| M9313 | 25-Hydroxycholesterol | Others |
| 25-Hydroxycholesterol is a cholesterol metabolite produced and secreted by macrophages in response to toll-like receptor (TLR) activation. 25-Hydroxycholesterol effectively and selectively inhibited IgA production in B cells with EC50 of about 65 nM. | ||
| M10348 | 27-Hydroxycholesterol | Estrogen Receptor |
| 27-Hydroxycholesterol is a selective estrogen receptor modulator, and it is also an agonist of the liver X receptor. | ||
| M13771 | BODIPY-Cholesterol | Fluorescent Dye |
| BODIPY-cholesterol is an intrinsically lipophilic, and cell-permeable analog of cholesterol with a fluorescent BODIPY group. | ||
| M18170 | 7-Dehydrocholesterol acetate | Others |
| 7-Dehydrocholesterol acetate | ||
| M18253 | 7alpha-Hydroxycholesterol | Others |
| 7alpha-Hydroxycholesterol | ||
| M18414 | 7-Dehydrocholesterol | Ferroptosis |
| 7-DHC | ||
| 7-Dehydrocholesterol (7-DHC) is a metabolic intermediate in cholesterol synthesis as well as an unsaturated sterol whose conjugated double bond on the sterol's B ring allows 7-DHC to take up free radicals, thereby counteracting the ability of free radicals to trigger lipid oxidation and iron death. | ||
| M20876 | Dihydrocholesterol | Others |
| Beta-Cholestanol, Zymostanol, 5alpha-Cholestanol | ||
| Dihydrocholesterol is a cholesterol derivative found in human feces, gallstones, eggs, and other biological matter. | ||
| M21702 | 22(R)-Hydroxycholesterol | Metabolite/Endogenous Metabolite |
| 22(R)-Hydroxycholesterol is an intermediate of the pregnenolone synthesis pathway from cholesterol. It has neuroprotective properties and protects the neurons against β-amyloid-induced cell death. | ||
| M21968 | Cholesterol Margarate | Others |
| Cholesterol Margarate | ||
| M22127 | Cholesterol-d7 | Others |
| Cholesterol-d7 | ||
| M28685 | Cholesterol 24-hydroxylase-IN-1 | Cytochrome P450 (e.g. CYP17) |
| Cholesterol 24-hydroxylase-IN-1 (compound 17) is a potent, orally active, and highly selective cholesterol 24-hydroxylase (CH24H or CYP46A1) inhibitor (IC50=8.5 nM). Cholesterol 24-hydroxylase-IN-1 can cross blood-brain barrier. | ||
| M28783 | DC-Chol hydrochloride | Amyloid |
| DC-Cholesterol hydrochloride | ||
| DC-Chol hydrochloride could inhibit Aβ40 fibril formation under appropriate experimental conditions. DC-Chol hydrochloride strongly inhibits amyloidogenesis of oxidized hCT in a dose-dependent manner. | ||
| M30042 | Cholesterol 5beta,6beta-epoxide | Others |
| Cholesterol beta-epoxide | ||
| Cholesterol 5beta,6beta-epoxide is an oxidative metabolite of cholesterol formed by free-radical and non-radical oxidation of cholesterol at the 5,6 double bond. Cholesterol 5beta,6beta-epoxide induces lactate dehydrogenase (LDH) release and apoptosis in macrophage-differentiated U937 cells. | ||
| M30136 | 24-Methylenecholesterol | Transferase |
| Ostreasterol | ||
| 24-Methylenecholesterol (Ostreasterol), a natural marine sterol, stimulates cholesterol acyltransferase in human macrophages. 24-Methylenecholesterol possess anti-aging effects in yeast. 24-methylenecholesterol enhances honey bee longevity and improves nurse bee physiology. | ||
| M30137 | 24(S)-Hydroxycholesterol | Liver X Receptor |
| 24S-OHC; 24S-HC; Cerebrosterol | ||
| 24(S)-Hydroxycholesterol (24S-OHC), the major brain cholesterol metabolite, plays an important role to maintain homeostasis of cholesterol in the brain. 24(S)-Hydroxycholesterol (24S-OHC) is one of the most efficient endogenous LXR agonist known and is present in the brain and in the circulation at relatively high levels. 24(S)-Hydroxycholesterol (24S-OHC) is a very potent, direct, and selective positive allosteric modulator of NMDARs with a mechanism that does not overlapthat of other allosteric modulators. | ||
| M30428 | 7α,25-Dihydroxycholesterol | GPR/FFAR |
| 7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol is highly potent at activating EBI2 (EC50=140 pM; Kd=450 pM). 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells. | ||
| M39576 | Cholesterol 5α,6α-epoxide | Others |
| Cholesterol-5α,6α-epoxide is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||
| M39737 | 7β-Hydroxycholesterol | Others |
| 7β-Hydroxycholesterol is an oxysterol that derived by the oxidation of cholesterol. 7β-hydroxycholesterol is a powerful inducer of oxidative stress, inducing dysfunction of organelles (mitochondria, lysosomes and peroxisomes) that can cause cell death. | ||
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