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Cholesterol 5beta,6beta-epoxide

Cat. No. M30042
Cholesterol 5beta,6beta-epoxide Structure
Synonym:

Cholesterol beta-epoxide

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Quality Control & Documentation
Biological Activity

Cholesterol 5beta,6beta-epoxide is an oxidative metabolite of cholesterol formed by free-radical and non-radical oxidation of cholesterol at the 5,6 double bond. Cholesterol 5beta,6beta-epoxide induces lactate dehydrogenase (LDH) release and apoptosis in macrophage-differentiated U937 cells.

Chemical Information
Molecular Weight 402.65
Formula C27H46O2
CAS Number 4025-59-6
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Sinéad Lordan, et al. J Biochem Mol Toxicol. The role of calcium in apoptosis induced by 7beta-hydroxycholesterol and cholesterol-5beta,6beta-epoxide

[2] Sinead Lordan, et al. Int J Toxicol. Involvement of Fas signalling in 7beta-hydroxycholesterol-and cholesterol-5beta,6beta-epoxide-induced apoptosis

[3] Sinéad Lordan, et al. J Biochem Mol Toxicol. Death-signaling pathways in human myeloid cells by oxLDL and its cytotoxic components 7beta-hydroxycholesterol and cholesterol-5beta,6beta-epoxide

[4] L Ryan, et al. Int J Toxicol. Involvement of calcium in 7beta -hydroxycholesterol and cholesterol-5beta,6beta -epoxide-induced apoptosis

[5] Lisa Ryan, et al. Br J Nutr. The role of the mitochondria in apoptosis induced by 7beta-hydroxycholesterol and cholesterol-5beta,6beta-epoxide

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