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Abmole Inhibitor Catalog 2017

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Cat.No.  Name Information
M6282 NSC23766 NSC 23766 is an inhibitor of Rac GTPase targeting Rac activation by guanine nucleotide exchange factors (GEFs) with IC50 of ~50 μM in a cell-free assay; does not inhibit the closely related targets, Cdc42 or RhoA.
M6281 (R)-Budesonide Budesonide is a GC steroid commonly used for the treatment of asthma and non-infectious rhinitis.
M6280 Brequinar Brequinar is a potent inhibitor of dihydroorotate dehydrogenase, with potent activities against a broad spectrum of viruses.
M6279 Laropiprant Laropiprant is a potent, selective DP1 receptor antagonist with Ki value of 0.57 nM, and exhibits > 1,000 fold selectivity over DP2 receptor (Ki=0.75 μM).
M6276 Thiazolidine Thiazolidinediones (TZDs) are peroxisome proliferator-activated receptor γ agonists that improve insulin-mediated glucose uptake and possess beneficial vasculoprotective actions.
M6275 PF 429242 PF-429242 efficiently prevented the processing of GPC from the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) and LASV, which correlated with the compound's potent antiviral activity against LCMV and LASV in cultured cells.
M6274 Tenofovir Disoproxil Tenofovir dsoproxil is a nucleotide reverse transcriptase inhibitor to treat HIV and chronic Hepatitis B.
M6273 Varenicline tartrate Varenicline Tartrate is a nicotinic AChR partial agonist, used to treat nicotine addiction.
M6272 PF04971729 PF-04971729 (Ertugliflozin) is a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2).
M6270 (S)-PMPA PMPA significantly inhibits viral reverse transcription and has been reported to sustain low virus load in SIV-infected rhesus monkeys.
M6268 Varenicline Varenicline(CP 526555;Champix) is a selective α4β2 nicotinic receptor partial agonist; it stimulates nicotine receptors more weakly than nicotine itself does.
M6265 BMS 309403 BMS-309403 is a potent, selective and cell-permeable inhibitor of fatty acid binding protein 4 (FABP4) with a Ki of less than 2 nM.
M6262 Fadrozole Fadrozole is a potent, selective and nonsteroidal inhibitor of aromatase with an IC50 of 6.4 nM.
M6261 PKM2 inhibitor PKM2 inhibitor displays PKM2 inhibitory activity with the IC50 value of 2.95 μM. The IC50 value for PKM1 is 4-5-fold higher than that for PKM2.
M6258 CA-4948 CA-4948 is a reversible kinase inhibitor that modulates IRAK4 function in both the toll-like receptor (TLR) and interleukin 1 receptor (IL-1R) signaling cascades, and demonstrates pharmacodynamic and antitumor activity in in vitro and in vivo nonclinical models.
M6257 ONC212 ONC212, a fluorinated-ONC201 analogue, is broadly efficacious across most solid tumors and hematological malignancies in the low nanomolar range and has robust anti-leukemic activity.
M6255 JPH203 JPH203, a selective L-type amino acid transporter 1 inhibitor, shows a dramatic inhibition of leucine uptake (IC50=0.06 µM) and cell growth (IC50=4.1 µM) in human colon cancer cells (HT-29), human oral cancer cells (YD-38) and leukemic cells.
M6252 Sulbutiamine Sulbutiamine is a highly lipid soluble synthetic analogue of vitamin B1, used for the treatment of asthenia.
M6251 R-IMPP R-IMPP is an inhibitor of PCSK9 secretion.
M6250 AM-0902 AM-0902 is a potent, selective antagonist of TRPA1 with IC50s of 71 and 131 nM for rTRPA1 and hTRPA1, respectively.
M6249 BMS-813160 BMS-813160 is the first dual CCR2/CCR5 antagonist to enter clinical development for cardiovascular.
M6248 BMS-986205 BMS-986205 is a selective indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor.
M6247 VU6005649 VU6005649 is a CNS penetrant mGlu7/8 receptor agonist with EC50s of 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively.
M6246 TLR7-agonist-1 TLR7-agonist-1 is a potent and selective Toll-like Receptor 7 (TLR7) agonist with a LEC of 0.4 μM.
M6245 Basmisanil Basmisanil is a highly selective GABAAα5 negative allosteric modulator.
M6244 eFT-508 eFT-508 (eFT508) is a potent and selective MNK1/2 inhibitor with IC50s of 2.4 nM and 1 nM, respectively. It potentially results in decreased tumor cell proliferation and tumor growth.
M6243 Vorapaxar Sulfate Vorapaxar is a first-in-class, potent and orally-active protease-activated receptor 1 (PAR-1) antagonist that blocks thrombin-mediated platelet activation without interfering with thrombin-mediated fibrin deposition.
M6242 DCMU DCMU is a herbicide that inhibits photosynthesis.
M6241 Tenovin 6 Hydrochloride Tenovin-6 Hydrochloride is a water soluble inhibitor of SIRT1 and SIRT2, slightly inhibits HDAC8, and is also a potent activator of p53, with IC50s of 21 μM, 10 μM, 67 μM for SirT1, SirT2, and SirT3, respectively.
M6240 Angiotensin II human Angiotensin II human is converted by Angiotensin I through removal of two C-terminal residues by the enzyme angiotensin-converting enzyme (ACE). Angiotensin II is mediated by AT1 and AT2 receptors, which are seven transmembrane glycoproteins with 30% sequence similarity.
M6239 Delpazolid Delpazolid is a novel oxazolidinone antibiotic agent which can inhibit the growth of MSSA and MRSA with a MIC90 of 2 μg/mL for both of them.
M6236 CA-074 Me CA-074 Me is a membrane-permeable derivative of CA-074 and acts as an irreversible cathepsin B inhibitor.
M6234 Z-FA-FMK Z-FA-FMK is an irreversible cysteine protease inhibitor, and also inhibits effector caspases.
M6229 Kanamycin sulfate Kanamycin (sulfate) is an aminoglycoside antibiotic, available in oral, intravenous, and intramuscular forms, and used to treat a wide variety of infections.
M6228 Wilforine Wilforine is a sesquiterpene pyridine alkaloid; important bioactive compound in T. wilfordii plants, and is effective in treating idiopathic pulmonary fibrosis.
M6227 Wilfortrine Wilfortrine is an immunomodulatory compound isolated from Tripterygium wilfordii.
M6224 Etanercept Etanercept is a dimeric fusion protein consisting of two ligand-binding domains of human p75 tumor necrosis factor receptor and the human IgG1 Fc portion.
M6223 Tocilizumab Tocilizumab is a humanized monoclonal antibody that binds to the interleukin-6 receptor, MW: 148 KD.
M6220 Lambrolizumab Lambrolizumabis a potent, highly selective, fully humanized immunoglobulin (Ig) G4-kappa monoclonal antibody against PD-1 with potential immune checkpoint inhibitory and antineoplastic activities. MW : 146.286 KD.
M6219 Rituximab Rituximab is a chimeric anti-CD20 mAb that binds the CD20 antigen on B cells with a binding affinity of 5 nM, MW: 143.86 KD.
M6216 TAPI-2 TAPI-2 is a broad-spectrum inhibitor of matrix metalloprotease (MMP), tumour necrosis factorα-converting enzyme (TACE) and a disintegrin and metalloproteinase (ADAM), with an IC50 of 20±10 μM for MMP.
M6215 TAPI-0 TAPI-0 is an inhibitor which blocks the maturation of cytokines, soluble cyokine receptors and other proteins that require the action of proteases.
M6214 6-Maleimidocaproic Acid A sulfhydryl reactive heterobifunctional crosslinking reagent. Widely used probe for introducing maleimides groups into biomolecules. A probe for thiol groups in proteins.
M6213 6-Maleimidohexanoic acid N-hydroxysuccinimide ester 6-Maleimidohexanoic acid N-hydroxysuccinimide ester(ECMS) is a useful protective group in antibody drug conjugates.
M6212 BAY-1436032 BAY1436032 specifically inhibits R-2HG production and colony growth, and induces myeloid differentiation of AML cells.
M6210 2-Thenoyltrifluoroacetone 2-Thenoyltrifluoroacetone, the archetype representative of Complex II inhibitors, binds to the ubiquinone-binding site of Complex II, thereby blocking electron transfer, which causes electron slippage and superoxide production.
M6209 Rotenone Rotenone is an inhibitor of mitochondrial electron transport at NADH:ubiquinone oxidoreductase, and is used to induce a Parkinson-like syndrome as an experimental model in rats.
M6208 2-Chloro-5- nitro-benzeneacetic acid
M6207 FX1 FX1 is a potent and specific BCL6 inhibitor, with an IC50 of around 35 μM.
M6204 GC376 GC376 is a 3CLpro inhibitor; inhibits the replication of viruses TGEV, FIPV and PTV with IC50 values of 0.15, 0.2 and 0.15 μM.

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