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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M9788 | PF-9366 | PF-9366 is a novel inhibitor of human methionine adenosyltransferase 2A (Mat2A), with IC50 of 420 nM and Kd of 170 nM. |
| M9787 | Aminopterin | Aminopterin is a folic acid derivative used as a rodenticide that has been shown to be teratogenic, and a dihydrofolate reductase inhibitor used to treat rheumatoid arthritis and leukemia. |
| M9783 | Sodium oxamate | Sodium oxamate is a competitive LDHA (actate dehydrogenase A) inhibitor, it inhibits L(+)-lactate dehydrogenase and derails the entire gluconeogenic pathway. |
| M9778 | Voxelotor | Voxelotor (GBT440) is a hemoglobin S allosteric modulator. |
| M9777 | 4-Nitroimidazole | 4-Nitroimidazole is an intermediate during the synthesis of 1-methyl-2,4,5-trinitro imidazole. |
| M9773 | Triacetyl-ganciclovir | Triacetyl-ganciclovir is related to ganciclovir, which may be used for toxicity studies and other analytical studies during commercial production of Ganciclovir. |
| M9771 | TRAP-6 | TRAP-6 (Thrombin Receptor Activator Peptide 6) is a peptide fragment (residues 42-47) of protease-activated receptor 1 (PAR1) that acts as a PAR1 agonist. |
| M9770 | Riboflavin phosphate sodium | Riboflavin phosphate sodium is the phosphate sodium salt form of riboflavin, a water-soluble and essential micronutrient that is the principal growth-promoting factor in naturally occurring vitamin B complexes. |
| M9766 | GNE-1858 | GNE-1858 is a potent, and ATP-competitive inhibitor of hematopoietic progenitor kinase-1 (HPK1). |
| M9765 | Dimethyl itaconate | Dimethyl itaconate may be used in functionalization of isotactic poly(propylene). |
| M9750 | Vipivotide tetraxetan | Vipivotide tetraxetan (PSMA-617) is a potent prostate-specific membrane antigen (PSMA) inhibitor with Ki value of 0.37 nM, it is used to make 177Lu-PSMA-617, which is a radioactive molecule to fight cancer. |
| M9745 | DIDS sodium salt | DIDS sodium salt (MDL101114ZA) is a dual ABCA1 and VDAC1 inhibitor. DIDS sodium salt is also an anion transport inhibitor, which inhibits the ClC-Ka chloride channel and the bacterial ClC-ec1Cl-/H+ exchanger with IC50s of 100 μM and ~300 μM, respectively. |
| M9744 | QM385 | QM385 is a potent sepiapterin reductase (SPR) inhibitor with IC50 of 1.49 nM. |
| M9736 | VHL Ligand 1 hydrochloride | VHL Ligand 1 hydrochloride is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. |
| M9735 | ND-646 | ND-646 is an allosteric inhibitor of the ACC enzymes ACC1 and ACC2 with IC50 values of 3.5 nM and 4.1 nM for recombinant hACC1 and hACC2, respectively. |
| M9734 | 4-Nitrophenyl N-acetyl-β-D-glucosaminide | 4-Nitrophenyl N-acetyl-β-D-glucosaminide is a chromogenic substrate for N-acetyl-glucosaminidase. |
| M9733 | Eliglustat tartrate | Eliglustat tartrate is a potent and selective glucosylceramide synthase inhibitor with IC50 of 24 nM. |
| M9732 | Gadopentetate dimeglumine | Gadopentetate dimeglumine is used in combination with magnetic resonance imaging (MRI) to allow blood vessels, organs, and other non-bony tissues to be seen more clearly on the MRI. |
| M9731 | Indoxyl sulfate potassium salt | Indoxyl sulfate potassium salt (Potassium 1H-indol-3-yl sulfate) is a metabolite of tryptophan derived from dietary protein. |
| M9730 | CTLA-4 inhibitor 1 | CTLA-4 inhibitor 1 is a potent B7.1-CD28 interaction inhibitor with IC50 of 50 nM. |
| M9726 | GLX351322 | GLX351322 is an NADPH oxidase 4 inhibitor, which inhibits hydrogen peroxide production from tetracycline inducible NOX4-overexpressing cells with IC50 of 5 uM. |
| M9725 | Ponalrestat | Ponalrestat is an orally active, selective and noncompetitive aldose reductase inhibitor. |
| M9717 | Etosalamide | Etosalamide (also known as Ethosalamide) is an antipyretic and analgesics agent. |
| M9716 | AKOS B018304 | AKOS B018304 is a potent inhibitor of chikungunya virus with low micro molar activity. |
| M9712 | Pyrocatechuic acid | Pyrocatechuic acid (2,3-Dihydroxybenzoic acid) is a normal human benzoic acid metabolite found in plasma, and has increased levels after aspirin ingestion. |
| M9708 | Chymotrypsin | α-Chymotrypsin is a serine peptidase and has 241 amino acid residues contained in three polypeptide chains (A chain-13 residues, B chain-131 residues, and C chain-97 residues) linked by disulfide bridges. |
| M9707 | HAMNO (NSC111847) | HAMNO (NSC111847) is a potent and selective inhibitor of replication protein A (RPA) interactions with proteins involved in the replication stress response. |
| M9704 | Shield-1 | Shield-1 is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP. |
| M9703 | Hexadimethrine bromide | Hexadimethrine bromide can be used to transfect mammalian cells with DNA. It can be used to increase the efficiency of lipofection transfections. |
| M9701 | Diethylenetriaminepentaacetic acid | Diethylenetriaminepentaacetic acid is a diethylenetriaminepentaacetic anhydride, which is a bifunctional chelating agent. |
| M9698 | D-(+)-Trehalose dihydrate | D-(+)-Trehalose is a non-reducing sugar, used as a food ingredient and pharmaceutical excipient. |
| M9690 | PEO-IAA | PEO-IAA is a novel potent auxin antagonist, which binds to transport inhibitor response 1/auxin signaling F-box proteins (TIR1/AFBs). |
| M9681 | 6-Methoxynicotinamide | 6-Methoxynicotinamide is a potent Nicotinamide N-methyltransferase (NNMT) inhibitor with IC50s of 1.8 µM, 2.8 µM, and 5.0 µM for human NNMT, monkey NNMT and mouse NNMT, respectively. |
| M9680 | 3-Bromopyruvic acid | 3-Bromopyruvic acid is a hexokinase II inhibitor, which is an effective antitumor agent on the hepatoma cells. |
| M9677 | TM5441 | TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor-1 (PAI-1), with IC50 values between 13.9 and 51.1 μM against several human cancer cell lines. |
| M9673 | Theocardin | Theocardin |
| M9672 | 5-Chloropyridazine-3,4-diamine | 5-Chloropyridazine-3,4-diamine |
| M9671 | KF 17837 | KF 17837 |
| M9670 | (±)-1-(9-Fluorenyl)ethanol | (±)-1-(9-Fluorenyl)ethanol |
| M9669 | 1H-pyrazolo[1,5-a]pyridin-5-one | 1H-pyrazolo[1,5-a]pyridin-5-one |
| M9668 | 6-chloropyrido[3,2-d]pyrimidine-2,4-diamine | 6-chloropyrido[3,2-d]pyrimidine-2,4-diamine |
| M9667 | HADA | HADA |
| M9666 | 2,4-dichloro-5,7-dimethoxyquinoline | 2,4-dichloro-5,7-dimethoxyquinoline |
| M9665 | N-(2-amino-2-oxoethyl)acrylamide | N-(2-Amino-2-oxoethyl)acrylamide |
| M9662 | 2-(4-Methylpiperazin-1-yl)pyrimidine | 2-(4-Methylpiperazin-1-yl)pyrimidine |
| M9661 | MF-438 | MF-438 is a potent and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor with an EC50 of 2.3 nM for rSCD1. |
| M9660 | Bis(triphenylphosphine)palladium(II) dichloride | Bis(triphenylphosphine)palladium(II) dichloride |
| M9659 | Rac-Modipafant | Rac-Modipafant (UK-74505) is an orally active, selective, long-acting irreversible platelet activating factor receptor (PAFR) antagonist. |
| M9658 | 1-Bromo-4-(1-fluorovinyl)benzene | 1-Bromo-4-(1-fluorovinyl)benzene |
| M9657 | 7-Bromoquinoline-4-carboxylic acid | 7-Bromoquinoline-4-carboxylic acid |
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