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Inhibitors
| Cat.No. | Name | Information |
|---|---|---|
| M2497 | Cathepsin Inhibitor 1 | Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively. |
| M5083 | β-Cyclodextrin | β-Cyclodextrin affects the formation of isomerization products during peptide deamidation. |
| M2189 | MLN4924 | MLN4924 is a novel small molecule NAE inhibitor with IC50 of 4 nM. |
| M8974 | ALW-II-41-27 | ALW-II-41-27 is a Eph receptor tyrosine kinase inhibitor with an IC50 of 11 nM for EPHA2. |
| M5708 | Iohexol | Iohexol is a contrast agent which can be applied for myelography, computerized tomography (cisternography, ventriculography) and MicroCT imaging in vivo. |
| M21538 | Diphenyl diselenide | Diphenyl diselenide inhibits δ-aminolevulinic acid dehydrase (δ-ALA-D) in brain, liver, and kidney in vivo. |
| M21536 | BAY-069 | BAY-069 is a branched-chain amino acid transaminase (BCAT) 1/2 inhibitor. Involved in the synthesis and catabolism of branched-chain amino acids. |
| M21535 | UCB7362 | UCB7362 is an oral plasma protease X (PMX) inhibitor that is being developed as an anti-malarial compound. |
| M21534 | AN15368 | AN15368 is an oral cleavage and polyadenylate specific factor (CPSF3) inhibitor being developed for use in Chagas disease (also known as American trypanosomiasis). |
| M21532 | JNJ-64264681 | JNJ-64264681 is a covalent Bruton tyrosine kinase (BTK) inhibitor under development for hematological malignancies. |
| M21528 | 1-Carbamoylcyclopropanecarboxylic acid | |
| M21527 | MES hydrate | MES is a buffer solution. MES is an amphoteric ion N- substituted sulfamic acid with a morpholine ring. This composition does not form complexes with most metals used in environmental and biological research. It is soluble in water but extremely insoluble in lipids, and therefore unable to penetrate membranes. |
| M21511 | RGLS4326 | RGLS4326 (RG4326) is a first-in-class microRNA-17 (miR-17) oligonucleotide inhibitor. RGLS4326 can be used in the study of autosomal dominant polycystic kidney disease (ADPKD). RGLS4326 acts on HeLa cells to inhibit the function of miR-17 with EC50 value of 28.3 nM. |
| M21510 | Telaglenastat hydrochloride | Telaglenastat (CB-839) hydrochloride is a pioneering (first-in-class), selective, reversible, orally active glutaminase 1 (GLS1) inhibitor. Telaglenastat hydrochloride has IC50 values of 23 nM and 28 nM for endogenous glutaminase in the kidney and brain of mice, respectively. Telaglenastat hydrochloride also induces autophagy and has strong antitumor activity. |
| M21508 | Ibezapolstat | Ibezapolstat (ACX-362E) is a first-of-its-kind (first-in-class) inhibitor of the orally active DNA polymerase IIIC (DNA pol IIIC) developed for use in the study of Clostridium difficile infection (CDI). |
| M21502 | FBA-IN-1 | FBA-IN-1 is a pioneer, covalent allosteric inhibitor of 1, 6-bisphosphate fructoalbinase (CaFBA) from Candida albicans. FBA-IN 1 inhibited the growth of azole resistant strain 103 with MIC80 of 1 μg/mL. |
| M21501 | Monalizumab | Monalizumab is a first-in-class immune checkpoint inhibitor targeting natural killer cell population 2A (NKG2A). Monalizumab can be used in the study of head and neck squamous cell carcinoma (HNSCC). |
| M21499 | Rodatristat ethyl | Rodatristat ethyl (KAR5585) was a first-in-class inhibitor of tryptophan hydroxylase 1 (TPH1) with oral activity. |
| M21497 | Gemcabene calcium | Gemcabene calcium (PD-72953 calcium), the pioneering (first-in-class) lipid-lowering agent, can lower density lipoprotein cholesterol (LDL-C), lower triglycerides, and increase high-density lipoprotein cholesterol (HDL-C), and lower pro-inflammatory acute phase proteins. C-reactive protein (CRP), which shows anti-inflammatory activity. |
| M21494 | Sibofimloc | Sibofimloc (CD-202) is a first-in-class, intestinal limiting and oral active inhibitor of FimH adhesion. Sibofimloc has antibacterial activity and is being developed for the study of inflammatory bowel disease (IBD). |
| M21493 | Omadacycline mesylate | Omadacycline (PTK 0796) mesylate, the first (first-in-class) orally active aminomethylcycline antibiotic, is a tetracycline antibiotic. Omadacycline mesylate can be used to study acute bacterial skin and skin structure infections, infectious pneumonia, and urinary tract infections. |
| M21492 | Omadacycline | Omadacycline (PTK 0796) tosylate, the first (first-in-class) orally active aminomethylcycline antibiotic, is a tetracycline antibiotic. Omadacycline tosylate can be used to study acute bacterial skin and skin structure infections, infectious pneumonia, and urinary tract infections. |
| M21490 | Omadacycline hydrochloride | Omadacycline (PTK 0796) hydrochloride, as a tetracycline antibiotic, is the first (first-in-class) orally active aminomethylcycline antimicrobial agent. Omadacycline hydrochloride is used to study acute bacterial skin and skin structure infections, infectious pneumonia, and urinary tract infections. |
| M21489 | Secukinumab | Secukinumab (AIN457) is a high-affinity monoclonal antibody against interleukin (IL-17A). Secukinumab (AIN457) is a first-in-class anti-IL-17 agent in the study of plaque psoriasis, ankylosing spondylitis, and psoriatic arthritis. |
| M21485 | Acotiamide-d6 | Acotiamide-d6 (Z-338-d6 free base) is a deuterium substitute of Acotiamide. Acotiamide is a first-in-class gastrointestinal motility compound with oral activity that has the potential to be used in functional dyspepsia. |
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