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Inhibitors

Cat.No.	Name	Information
M6145	BMS-5	BMS-5 is a Potent LIM kinase inhibitor (IC50 values are 7 and 8 nM for LIMK1 and LIMK2 respectively).Inhibits cofilin phosphorylation in MDA-MB-231 breast cancer cells. Reduces MDA-MB-231 tumor cell invasion in a 3D matrigel invasion assay.
M6144	BMS-3	BMS-3 is a potent inhibitor of LIMK1.LIM kinase 1 (LIMK1) activity is essential for cell migration and cell cycle progression.
M6138	E-7046	E7046 is an orally bioavailable and specific EP4 antagonist, with IC50 of 13.5 nM and Ki of 23.14 nM, exhibiting anti-tumor activities.
M6137	PF-05175157	PF-05175157 (Compound 9) is a potent Acetyl-CoA carboxylase (ACC1) inhibitor with IC50s of 23.5±1.1 nM (rat) and 27.0±2.7 nM (human).
M6136	Epacadostat	Epacadostat (INCB024360) is a potent and selective indoleamine 2,3-dioxygenase (IDO1) inhibitor with IC50 of 10 nM and displays high selectivity over other related enzymes such as IDO2 or tryptophan 2,3-dioxygenase (TDO).
M6135	Calicheamicins	The calicheamicins are a class of enediyne antitumor antibiotics derived from the bacterium Micromonospora echinospora, with calicheamicin γ1 being the most notable.
M6134	Tildipirosin	Tildipirosin is a derivative of the naturally occurring compound tylosin.
M6133	Oritavancin diphosphate	Oritavancin is approved for the treatment of adult patients with acute bacterial skin and skin structure infections (SSSIs) caused by or suspected to be caused by susceptible isolates of designated gram-positive microorganisms.
M6132	ECBN HCL	ECBN obtained by the fermentation of Aspergillus nidulans and Aspergillus rugulosus, is known as one of the natural cyclic hexapeptides that have a linoleoyl side chain, which inhibits a crucial enzyme in fungal cell wall biosynthesis, β-(1,3)-d-glucan synthase.
M6131	Pristinamycin	The pristinamycins exhibit a strong synergistic antibacterial activity against a wide range of Gram-positive and some Gram-negative bacteria, including methicillin- and vancomycin-resistant strains.
M6129	Dalfopristin	Dalfopristin is a semi-synthetic streptogramin antibiotic. Quinupristin/Dalfopristin (Q/D) is a valuable alternative antibiotic to vancomycin for the treatment of multi-drug resistant Enterococcus faecium infections.
M6127	TD-4208	TD-4208 is a novel and potent muscarinic receptor antagonist that has a high affinity and long residence time at the M3 receptor, and demonstrates in vitro kinetic selectivity for M3 over M2 muscarinic receptor subtype and no meaningful off-target activity.
M6126	Triazolo-pyramidine derivative	Triazolo-pyramidine derivative is a purine receptor antagonist.
M6125	AKP-11	AKP-11 has potent immune modulatory activity for treatment of EAE/MS, but with relatively low adverse effects suggesting AKP-11 as a potential therapeutic drug for MS patients.
M6115	Drostanolone Propionate	Drostanolone propionate can reduce the uptake of oestradiol-17B by tumour cells
M6113	Hastatoside	Hastatoside is isolated from Verbena species and exhibits various biological activities including sleep-promoting.
M6112	Thiamine chloride	Thiamine chloride —the biologically active form of vitamin B1—is vital for all cellular life because it is a co-factor for several essential enzymes.
M6110	Levomefolic acid	Levomefolic acid (5-MTHF) is the natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions.
M6109	Calcium N5-methyltetrahydrofolate	Calcium N5-methyltetrahydrofolate(NSC173328) is the calcium salt of levomefolic acid, which has been proposed for treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancers.
M6108	Levomefolate calcium	Levomefolate is an artificial form of folate.
M6107	Trenbolone	Trenbolone(β-Trenbolone) is a steroid used by veterinarians on livestock to increase muscle growth and appetite.
M6104	Ipilimumab	Ipilimumab is an immunomodulatory monoclonal antibody directed against the cell surface antigen CTLA-4 and also a type of immune checkpoint inhibitor. MW : 148 kD.
M6098	Baicalein	Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor, IC50 value of 3.12 mM.
M6093	SQ22536	SQ22536 is an inhibitor of adenylyl cyclase with an IC50 of 1.4 μM. It can inhibit PGE1-stimulated increases in cAMP levels in intact human platelets.
M6091	Cadazolid	Cadazolid, a novel fluoroquinolone-oxazolidinone antibiotic, exhibits potent in vitro activity against Clostridium difficile, including the epidemic BI/NAP1/027 strain.
M6090	Cilastatin	Cilastatin is a dehydropeptidase I inhibitor that acts on the brush border membrane of the proximal tubule to prevent accumulation of imipenem and toxicity.
M6087	LXR-623	LXR-623 is a novel liver X-receptor(LXR) agonist with IC50 values of 179 nM and 24 nM for LXR-α and LXR-β, respectively. It is orally bioavailable and readily passes the blood-brain barrier.
M6082	2,6-Dichloro-3,5-dimethoxyaniline	2,6-Dichloro-3,5-dimethoxyaniline is H3B-6275 intermediate.
M6079	Triiodothyronine	Triiodothyronine is a potent agonist of both thyroid hormone receptors TRα and Trβ with Kis of 2.3 nM for both.
M6078	CFI-402257	CFI-402257 is a highly selective and orally bioavailable TTK and Mps1 inhibitor with Kis of 0.1 and 0.09 nM, respectively.
M6076	Miquelianin	Miquelianin (Quercetin 3-O-glucuronide) is a metabolite of quercetin and a type of natural flavonoid.
M6075	HA15	HA15 is a molecule that targets specifically BiP/GRP78/HSPA5. HA15 displays anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells that developed resistance to BRAF inhibitors.
M6072	Iberdomide	Iberdomide (CC-220) is a cereblon modulator in clinical development for systemic lupus erythematosis. Iberdomide exhibits an IC50 of 60 nM in TR-FRET cereblon binding assay.
M6069	β-Estradiol 17-acetate	β-Estradiol 17-acetate is a metabolite of estradiol.
M6063	Zatebradine	Zatebradine(UL-FS49) is a potent HCN channels antagonist, which decreased the heartbeat in a reversible manner; 92% inhibition of the hHCN1-mediated current at 10 uM.
M6062	Xylose	Xylose is a sugar first isolated from wood.
M6059	Warfarin	Warfarin is one of the most widely used anticoagulant drugs worldwide, used in the prevention of thrombosis and thromboembolism, the formation of blood clots in the blood vessels and their migration elsewhere in the body.
M6055	Vitamin B12	Vitamin B12 is a water soluble vitamin with a key role in the normal functioning of the brain and nervous system, and for the formation of blood.
M6049	Vecuronium Bromide	Vecuronium is a non-depolarizing neuromuscular blocking agent, used for skeletal muscle relaxation during surgery.
M6047	Ursodiol	Ursodiol reduces cholesterol absorption and is used to dissolve (cholesterol) gallstones. (IC50=0.22 μM)
M6045	Urethane	Urethane is a kind of antineoplastic agent that is also used as a veterinary anesthetic. It is a intermediate in organic synthesis.
M6043	Ulipristal acetate	Ulipristal acetate(CDB2914) is a novel selective progesterone receptor modulator (SPRM) for the treatment of benign gynecological conditions such as uterine myoma.
M6041	Tylosin tartrate	Tylosin tartrate is a macrolide antibiotic approved for the control of mycoplasmosis in poultry.
M6040	Tropicamide	Tropicamide is an anticholinergic and a muscarinic receptor subtype M4-preferring antagonist with IC50 of 8.0 nM.
M6039	Trioxsalen	Trioxsalen is a furanocoumarin and a psoralen derivative, in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. After photoactivation it creates interstrand cross-links in DNA, which can cause programmed cell death.
M6038	Trimethadione	Trimethadione is an oxazolidinedione anticonvulsant; commonly used to treat epileptic conditions.
M6037	Trimetazidine dihydrochloride	Trimetazidine dihydrochloride is a kind of drug for treatment of chronic ischemic disorders. It improves myocardial glucose utilization through inhibition of fatty acid metabolism, known as fatty acid oxidation inhibitor.
M6032	Trihexyphenidyl HCl	Trihexyphenidyl hydrochloride is an antiparkinsonian agent of the antimuscarinic class.
M6031	Triclosan	Triclosan is a diphenyl ether derivative used in cosmetics and toilet soaps as an antiseptic. It has some bacteriostatic and fungistatic action.
M6030	Trichlormethiazide	Trichlormethiazide is a diuretic with properties similar to those of hydrochlorothiazide.

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