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Abmole Inhibitor Catalog 2017

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Inhibitors

Cat.No.  Name Information
M6145 BMS-5 BMS-5 is a Potent LIM kinase inhibitor (IC50 values are 7 and 8 nM for LIMK1 and LIMK2 respectively).Inhibits cofilin phosphorylation in MDA-MB-231 breast cancer cells. Reduces MDA-MB-231 tumor cell invasion in a 3D matrigel invasion assay.
M6144 BMS-3 BMS-3 is a potent inhibitor of LIMK1.LIM kinase 1 (LIMK1) activity is essential for cell migration and cell cycle progression.
M6138 E-7046 E7046 is an orally bioavailable and specific EP4 antagonist, with IC50 of 13.5 nM and Ki of 23.14 nM, exhibiting anti-tumor activities.
M6137 PF-05175157 PF-05175157 (Compound 9) is a potent Acetyl-CoA carboxylase (ACC1) inhibitor with IC50s of 23.5±1.1 nM (rat) and 27.0±2.7 nM (human).
M6136 Epacadostat Epacadostat (INCB024360) is a potent and selective indoleamine 2,3-dioxygenase (IDO1) inhibitor with IC50 of 10 nM and displays high selectivity over other related enzymes such as IDO2 or tryptophan 2,3-dioxygenase (TDO).
M6135 Calicheamicins The calicheamicins are a class of enediyne antitumor antibiotics derived from the bacterium Micromonospora echinospora, with calicheamicin γ1 being the most notable.
M6134 Tildipirosin Tildipirosin is a derivative of the naturally occurring compound tylosin.
M6133 Oritavancin diphosphate Oritavancin is approved for the treatment of adult patients with acute bacterial skin and skin structure infections (SSSIs) caused by or suspected to be caused by susceptible isolates of designated gram-positive microorganisms.
M6132 ECBN HCL ECBN obtained by the fermentation of Aspergillus nidulans and Aspergillus rugulosus, is known as one of the natural cyclic hexapeptides that have a linoleoyl side chain, which inhibits a crucial enzyme in fungal cell wall biosynthesis, β-(1,3)-d-glucan synthase.
M6131 Pristinamycin The pristinamycins exhibit a strong synergistic antibacterial activity against a wide range of Gram-positive and some Gram-negative bacteria, including methicillin- and vancomycin-resistant strains.
M6129 Dalfopristin Dalfopristin is a semi-synthetic streptogramin antibiotic. Quinupristin/Dalfopristin (Q/D) is a valuable alternative antibiotic to vancomycin for the treatment of multi-drug resistant Enterococcus faecium infections.
M6127 TD-4208 TD-4208 is a novel and potent muscarinic receptor antagonist that has a high affinity and long residence time at the M3 receptor, and demonstrates in vitro kinetic selectivity for M3 over M2 muscarinic receptor subtype and no meaningful off-target activity.
M6126 Triazolo-pyramidine derivative Triazolo-pyramidine derivative is a purine receptor antagonist.
M6125 AKP-11 AKP-11 has potent immune modulatory activity for treatment of EAE/MS, but with relatively low adverse effects suggesting AKP-11 as a potential therapeutic drug for MS patients.
M6115 Drostanolone Propionate Drostanolone propionate can reduce the uptake of oestradiol-17B by tumour cells
M6113 Hastatoside Hastatoside is isolated from Verbena species and exhibits various biological activities including sleep-promoting.
M6112 Thiamine chloride Thiamine chloride —the biologically active form of vitamin B1—is vital for all cellular life because it is a co-factor for several essential enzymes.
M6110 Levomefolic acid Levomefolic acid (5-MTHF) is the natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions.
M6109 Calcium N5-methyltetrahydrofolate Calcium N5-methyltetrahydrofolate(NSC173328) is the calcium salt of levomefolic acid, which has been proposed for treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancers.
M6108 Levomefolate calcium Levomefolate is an artificial form of folate.
M6107 Trenbolone Trenbolone(β-Trenbolone) is a steroid used by veterinarians on livestock to increase muscle growth and appetite.
M6104 Ipilimumab Ipilimumab is an immunomodulatory monoclonal antibody directed against the cell surface antigen CTLA-4 and also a type of immune checkpoint inhibitor. MW : 148 kD.
M6098 Baicalein Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor, IC50 value of 3.12 mM.
M6093 SQ22536 SQ22536 is an inhibitor of adenylyl cyclase with an IC50 of 1.4 μM. It can inhibit PGE1-stimulated increases in cAMP levels in intact human platelets.
M6091 Cadazolid Cadazolid, a novel fluoroquinolone-oxazolidinone antibiotic, exhibits potent in vitro activity against Clostridium difficile, including the epidemic BI/NAP1/027 strain.
M6090 Cilastatin Cilastatin is a dehydropeptidase I inhibitor that acts on the brush border membrane of the proximal tubule to prevent accumulation of imipenem and toxicity.
M6087 LXR-623 LXR-623 is a novel liver X-receptor(LXR) agonist with IC50 values of 179 nM and 24 nM for LXR-α and LXR-β, respectively. It is orally bioavailable and readily passes the blood-brain barrier.
M6082 2,6-Dichloro-3,5-dimethoxyaniline 2,6-Dichloro-3,5-dimethoxyaniline is H3B-6275 intermediate.
M6079 Triiodothyronine Triiodothyronine is a potent agonist of both thyroid hormone receptors TRα and Trβ with Kis of 2.3 nM for both.
M6078 CFI-402257 CFI-402257 is a highly selective and orally bioavailable TTK and Mps1 inhibitor with Kis of 0.1 and 0.09 nM, respectively.
M6076 Miquelianin Miquelianin (Quercetin 3-O-glucuronide) is a metabolite of quercetin and a type of natural flavonoid.
M6075 HA15 HA15 is a molecule that targets specifically BiP/GRP78/HSPA5. HA15 displays anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells that developed resistance to BRAF inhibitors.
M6072 Iberdomide Iberdomide (CC-220) is a cereblon modulator in clinical development for systemic lupus erythematosis. Iberdomide exhibits an IC50 of 60 nM in TR-FRET cereblon binding assay.
M6069 β-Estradiol 17-acetate β-Estradiol 17-acetate is a metabolite of estradiol.
M6063 Zatebradine Zatebradine(UL-FS49) is a potent HCN channels antagonist, which decreased the heartbeat in a reversible manner; 92% inhibition of the hHCN1-mediated current at 10 uM.
M6062 Xylose Xylose is a sugar first isolated from wood.
M6059 Warfarin Warfarin is one of the most widely used anticoagulant drugs worldwide, used in the prevention of thrombosis and thromboembolism, the formation of blood clots in the blood vessels and their migration elsewhere in the body.
M6055 Vitamin B12 Vitamin B12 is a water soluble vitamin with a key role in the normal functioning of the brain and nervous system, and for the formation of blood.
M6049 Vecuronium Bromide Vecuronium is a non-depolarizing neuromuscular blocking agent, used for skeletal muscle relaxation during surgery.
M6047 Ursodiol Ursodiol reduces cholesterol absorption and is used to dissolve (cholesterol) gallstones. (IC50=0.22 μM)
M6045 Urethane Urethane is a kind of antineoplastic agent that is also used as a veterinary anesthetic. It is a intermediate in organic synthesis.
M6043 Ulipristal acetate Ulipristal acetate(CDB2914) is a novel selective progesterone receptor modulator (SPRM) for the treatment of benign gynecological conditions such as uterine myoma.
M6041 Tylosin tartrate Tylosin tartrate is a macrolide antibiotic approved for the control of mycoplasmosis in poultry.
M6040 Tropicamide Tropicamide is an anticholinergic and a muscarinic receptor subtype M4-preferring antagonist with IC50 of 8.0 nM.
M6039 Trioxsalen Trioxsalen is a furanocoumarin and a psoralen derivative, in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. After photoactivation it creates interstrand cross-links in DNA, which can cause programmed cell death.
M6038 Trimethadione Trimethadione is an oxazolidinedione anticonvulsant; commonly used to treat epileptic conditions.
M6037 Trimetazidine dihydrochloride Trimetazidine dihydrochloride is a kind of drug for treatment of chronic ischemic disorders. It improves myocardial glucose utilization through inhibition of fatty acid metabolism, known as fatty acid oxidation inhibitor.
M6032 Trihexyphenidyl HCl Trihexyphenidyl hydrochloride is an antiparkinsonian agent of the antimuscarinic class.
M6031 Triclosan Triclosan is a diphenyl ether derivative used in cosmetics and toilet soaps as an antiseptic. It has some bacteriostatic and fungistatic action.
M6030 Trichlormethiazide Trichlormethiazide is a diuretic with properties similar to those of hydrochlorothiazide.


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