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Dimethyl succinate (Standard for GC)

Cat. No. M10425
Dimethyl succinate (Standard for GC) Structure
Size Price Availability Quantity
1g USD 60  USD60 In stock
5g USD 120  USD120 In stock
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Quality Control & Documentation
Biological Activity

Dimethyl succinate is a biodegradable ester with low odor and low volatility and commonly serves as a flavoring agent that can be used in perfumery and personal are products, including skin-conditioning agents and emollient. Besides, dimethyl succinate can be used in the production of pharmaceuticals as well as agrochemicals and for manufacturing additives, plastics and other organic compounds.

Chemical Information
Molecular Weight 146.14
Formula C6H10O4
CAS Number 106-65-0
Solubility (25°C) Soluble in acetone
Water 3 mg/mL
Storage RT
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Mara Nez, et al. Polymers (Basel). Poly(butylene succinate- co-ε-caprolactone) Copolyesters: Enzymatic Synthesis in Bulk and Thermal Properties

[2] Paige C Arneson-Wissink, et al. JCSM Rapid Commun. The wasting-associated metabolite succinate disrupts myogenesis and impairs skeletal muscle regeneration

[3] A M Api, et al. Food Chem Toxicol. RIFM fragrance ingredient safety assessment Dimethyl succinate, CAS Registry Number 106-65-0

[4] Z Ruan, et al. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. [Determination in the air of workplace dimethyl succinate and dimethyl glutarate and dimethyl adipate by gas chromatography]

[5] Amy L Pochodylo, et al. Acta Crystallogr Sect E Struct Rep Online. catena-Poly[[diaqua-cadmium(II)]bis-(μ-2,2-dimethyl-butane-dioato-κO,O':O'',O''')[diaqua-cadmium(II)]-μ-1,4-bis-(3-pyridylmeth-yl)piperazine-κN:N]

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