D-Gluconic acid copper(II) salt

Biological Activity

D-gluconic acid copper (II) salt is the copper salt of D-gluconic acid that is an organic acid. It can be used as a buffer for encapsulating some compounds into liposomes. Copper is an essential microelement for human beings and animals; it is needed to absorb ion from and gut and can help regulate blood pressure and heart rate. It is also a key component of multiple enzymes involved in many biochemical reactions. In this sense, the D-gluconic acid copper (II) salt can be used as a copper supplement to treat the copper deficiency induced anemia and nephrosis.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)

Species	Mouse	Rat	Rabbit	Guinea pig	Hamster	Dog
Weight (kg)	0.02	0.15	1.8	0.4	0.08	10
Body Surface Area (m2)	0.007	0.025	0.15	0.05	0.02	0.5
Km factor	3	6	12	8	5	20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the K_m factor for a mouse and then divide by the K_m factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information

References

Enhanced aerobic exercise performance in women by a combination of three mineral Chelates plus two conditionally essential nutrients.
DiSilvestro RA, et al. J Int Soc Sports Nutr. 2017 Nov 13;14:42. PMID: 29158726.

Blocking the formation of radiation-induced breast cancer stem cells.
Wang Y, et al. Oncotarget. 2014 Jun 15;5(11):3743-55. PMID: 25003837.