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Eliglustat tartrate is a potent and selective glucosylceramide synthase inhibitor with IC50 of 24 nM. Incubating K562 or B16/F10 cells for 72 h with increasing amounts of Genz-112638 (0.6-1000 nM) results in a dose-dependent reduction of cell surface levels of both GM1 and GM3.
biorxiv. 2024 Apr 05.
Vesicle-mediated mitochondrial clearance underlies an actionable metabolic vulnerability in triple-negative breast cancer
Eliglustat tartrate purchased from AbMole
| Molecular Weight | 959.17 |
| Formula | C50H78N4O14 |
| CAS Number | 928659-70-5 |
| Solubility (25°C) | Water ≥ 48 mg/mL DMSO ≥ 48 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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