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(Z)-Akuammidine

Cat. No. M40014
(Z)-Akuammidine Structure
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Biological Activity

(Z)-Akuammidine ((Z)-Rhazine) is isolated from Gelsemium elegans.

Chemical Information
Molecular Weight 352.43
Formula C21H24N2O3
CAS Number 113973-31-2
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Allix Marie Coon et al. ACS Omega. Investigation of Small-Molecule Constituents in Voacanga africana Seeds and Mapping of Their Spatial Distributions Using Laser Ablation Direct Analysis in Real-Time Imaging-Mass Spectrometry (LADI-MS)

[2] Rubashiny Veeramohan et al. PLoS One. Comparative metabolomics analysis reveals alkaloid repertoires in young and mature Mitragyna speciosa (Korth.) Havil. Leaves

[3] Wen Chen et al. Nat Commun. Structure units oriented approach towards collective synthesis of sarpagine-ajmaline-koumine type alkaloids

[4] Yuanyuan Hou et al. J Chromatogr B Analyt Technol Biomed Life Sci. Microfractionation bioactivity-based ultra performance liquid chromatography/quadrupole time-of-flight mass spectrometry for the identification of nuclear factor-κB inhibitors and β2 adrenergic receptor agonists in an alkaloidal extract of the folk herb Alstonia scholaris

[5] Qiuping Zhang et al. Zhongguo Zhong Yao Za Zhi. [Chemical constituents of aerial parts of Gelsemium elegans]

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