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Voxelotor

Cat. No. M9778

All AbMole products are for research use only, cannot be used for human consumption.

Voxelotor Structure
Synonym:

GBT440

Size Price Availability Quantity
10mg USD 85  USD85 In stock
25mg USD 145  USD145 In stock
50mg USD 240  USD240 In stock
100mg USD 430  USD430 In stock
200mg USD 710  USD710 In stock
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Quality Control & Documentation
Biological Activity

Voxelotor (GBT 440) is a first-in-class, potent polymeric inhibitor of sickle hemoglobin (HbS). Voxelotor (GBT440) is first-in-class hemoglobin oxygen-affinity modulator. Voxelotor (GBT440) binds to the N-terminal a chain of haemoglobin (Hb), increases haemoglobin S (HbS) affinity for oxygen, delays in vitro HbS polymerization and prevents sickling of red blood cells (RBCs). Voxelotor has the potential to be used in sickle cell anaemia research.

In vivo, Voxelotor (GBT440; 100-150 mg/kg; administered twice a day by oral gavage for 9-12 days) reduces ex vivo sickling and prolongs red blood cells (RBCs) half-life in a murine model of sickle cell disease (SCD).

Chemical Information
Molecular Weight 337.37
Formula C19H19N3O3
CAS Number 1446321-46-5
Solubility (25°C) DMSO ≥ 90 mg/mL
Storage 2-8°C, dry, sealed
References

[1] Paul Telfer, et al. Hematol Rep. Impact of voxelotor (GBT440) on unconjugated bilirubin and jaundice in sickle cell disease

[2] Jeremie H Estepp. Am J Hematol. Voxelotor (GBT440), a first-in-class hemoglobin oxygen-affinity modulator, has promising and reassuring preclinical and clinical data

[3] Donna Oksenberg, et al. Br J Haematol. GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half-life in a murine model of sickle cell disease

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Keywords: Voxelotor, GBT440 supplier, inhibitors, activators

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