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Voxelotor

Cat. No. M9778
Voxelotor Structure
Synonym:

GBT440

Size Price Availability
10mg USD 150 4-7 Days
50mg USD 450 4-7 Days
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Voxelotor (GBT440) is a hemoglobin S allosteric modulator. Voxelotor (GBT440) increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half-life in a murine model of sickle cell disease.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 337.37
Formula C19H19N3O3
CAS Number 1446321-46-5
Purity >99%
Solubility DMSO ≥ 90 mg/mL
Storage 2-8°C, dry, protect from light, sealed
References

Impact of voxelotor (GBT440) on unconjugated bilirubin and jaundice in sickle cell disease
Paul Telfer, et al. Hematol Rep. 2018 May 22;10(2):7643. PMID: 30046415.

Voxelotor (GBT440), a first-in-class hemoglobin oxygen-affinity modulator, has promising and reassuring preclinical and clinical data
Jeremie H Estepp. Am J Hematol. 2018 Mar;93(3):326-329. PMID: 29352729.

GBT440 increases haemoglobin oxygen affinity, reduces sickling and prolongs RBC half-life in a murine model of sickle cell disease
Donna Oksenberg, et al. Br J Haematol. 2016 Oct;175(1):141-53. PMID: 27378309.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Voxelotor, GBT440 supplier, inhibitors

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