Product Name: | Voxelotor |
Catalog Number: | M9778 |
CAS Number: | 1446321-46-5 |
Formula: | C19H19N3O3 |
Molecular Weight: | 337.37 |
Solubility: | DMSO ≥ 90 mg/mL |
Storage: | 2-8°C, dry, sealed |
Chemical Structure: |
QC Standard: | >99% |
H-NMR: | Consistent with structure |
Description: | Voxelotor (GBT 440) is a first-in-class, potent polymeric inhibitor of sickle hemoglobin (HbS). Voxelotor (GBT440) binds to the N-terminal a chain of haemoglobin (Hb), increases haemoglobin S (HbS) affinity for oxygen, delays in vitro HbS polymerization and prevents sickling of red blood cells (RBCs). |
Stability and Solubility Advice: | Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details. |