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Matrine is a bioactive ingredient obtained from foxtail-like matrine herbs and seeds and is often used in oral cancer and chronic bronchial asthma studies. Sophorine is absorbed mainly by passive diffusion, and the vector mediated mechanism is also involved in sophorine transport. Sophorine can reduce the expression of TLR4 and inhibit the synthesis of pro-inflammatory cytokines in steatosis hepatocytes. NF-κB, JNK and ERK signaling pathways are important downstream pathways. Sophorine alleviates liver fibrosis mainly by inhibiting TLR4 pathway. Sophorine may be a potential chemotherapeutic agent for chronic liver disease. Sophorine has potential anti - fibrosis effect. The mechanism may be that the NF-κB signaling pathway regulates the balance between proinflammatory cytokines expression and collagen content and the expression of MMPs.
| Molecular Weight | 246.35 |
| Formula | C15H22N2O |
| CAS Number | 145572-44-7 |
| Form | Solid |
| Solubility (25°C) | DMSO >10 mM |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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