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Sagittatoside C

Cat. No. M40015
Sagittatoside C Structure
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Biological Activity

Sagittatoside C is a flavonoid isolated from Herba Epimedii.

Chemical Information
Molecular Weight 718.7
Formula C35H42O16
CAS Number 118525-37-4
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Lei Song et al. Comb Chem High Throughput Screen. Exploring Effects and Mechanism of Ingredients of Herba Epimedii on Osteogenesis and Osteoclastogenesis In Vitro

[2] Zhenghao Wang et al. J Microbiol Biotechnol. Icaritin Preparation from Icariin by a Special Epimedium Flavonoid-Glycosidase from Aspergillus sp.y848 Strain

[3] Yuping Shen et al. Enzyme Microb Technol. Convenient preparation of sagittatoside B, a rare bioactive secondary flavonol glycoside, by recyclable and integrated biphase enzymatic hydrolysis

[4] Yuping Shen et al. Nat Prod Res. Efficient preparation of rare Sagittatoside A from epimedin A, by recyclable aqueous organic two-phase enzymatic hydrolysis

[5] Yan Chen et al. Molecules. Role of intestinal hydrolase in the absorption of prenylated flavonoids present in Yinyanghuo

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