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S-(+)-Rolipram

Cat. No. M3375

S-(+)-Rolipram Structure
Size Price Availability Quantity
10mg USD 95 In stock
25mg USD 220 In stock
50mg USD 360 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

S- (+)-Rolipram is a less active enantiomer of the PDE4 inhibitor with an EC50 of 1.0 uM. It is an anti-inflammatory drug. Rolipram is being studied as a possible alternative to current antidepressants. Recent studies show that rolipram may have antipsychotic effects. It displays activity 10-fold less than R-rolipram at inhibition of PDE IV. It inhibits antigen-induced contraction of guinea-pig colonic smooth muscle.

Protocol
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models Male Hartley guinea pigs
Formulation S-(+)-Rolipram is dissolved in 100% PEG at an appropriate concentration.
Dosages 1 mL/kg
Administration Administered via i.v.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 275.34
Formula C16H21NO3
CAS Number 85416-73-5
Purity >99%
Solubility DMSO 50 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: S-(+)-Rolipram supplier, PDE, inhibitors

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