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Abmole Inhibitor Catalog 2017

PDE Phosphodiesterase


Cat.No.  Name Information
M10517 D159687 D159687 is a selective negative allosteric modulator (NAM) of PDE4D.
M10435 Difamilast Difamilast (OPA-15406) is a topical, highly selective and nonsteroidal phosphodiesterase-4 (PDE4) inhibitor.
M10179 Vesnarinone Vesnarinone is a cardiotonic agent, mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity.
M9882 Roflumilast N-oxide Roflumilast N-oxide is a phosphodiesterase 4 inhibitor.
M9679 CP671305 CP671305 is a potent and selective, orally active inhibitor of phosphodiesterase-4-D with high activities.
M9347 ITI-214 phosphate ITI-214 phosphate is an orally active, potent and selective inhibitors of PDE1, exhibits potent PDE1 inhibitory activity (Ki = 58 pM).
M6804 IBMX IBMX is a pDE inhibitor (non-selective) with IC50 values of 6.5±1.2, 26.3±3.9 and 31.7±5.3 μM for PDE3, 4 and 5 respectively.
M6287 GLPG1690 GLPG1690 (Ziritaxestat) is a first-in-class autotaxin (ATX) inhibitor, with IC50 of 131 nM and Ki of 15 nM.
M6153 E6005 RVT-501 (E6005) is a selective phosphodiesterase 4 (PDE4PDE4) inhibitor with an IC50 of 2.8 nM.
M6048 Vardenafil HCl Vardenafil Hcl is a PDE5 inhibitor used for treating erectile dysfunction.
M6042 Udenafil Udenafil(DA8159) is a PDE5 inhibitor used in urology to treat erectile dysfunction.
M6007 Theophylline Theophylline is a methylated xanthine derivative; competitive nonselective phosphodiesterase inhibitor and nonselective adenosine receptor antagonist.
M5960 Sildenafil Mesylate Sildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5.
M5959 Sildenafil Sildenafil is a Phosphodiesterase 5 Inhibitor with IC50 of 5.22 nM.
M5939 Rolipram The PDE4 selective inhibitor, rolipram, inhibited immunopurified PDE4B and PDE4D activities similarly, with IC50 values of approx. 130 nM and 240 nM respectively; an anti-inflammatory agent.
M5519 Cilostazol Cilostazol is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake.
M4964 HA130 HA130 is a selective ATX (autotaxin) inhibitor with IC50 of 28 nM.
M4851 TAK-063 TAK-063 is a highly potent, selective and orally active PDE10A inhibitor with IC50 of 0.30 nM.
M3588 Aminophylline Aminophylline is a competitive nonselective phosphodiesterase inhibitor with an IC50 of 0.12 mM and also a nonselective adenosine receptor antagonist.
M3587 Dyphylline Dyphylline is a xanthine derivative with bronchodilator and vasodilator effects.
M3566 Vardenafil hydrochloride Trihydrate Vardenafil hydrochloride Trihydrate is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.
M3473 Tadalafil Tadalafil is a PDE-5 inhibitor with IC50 of 1.8 nM.
M3447 PF-2545920 PF-2545920 is a potent and selective PDE10A inhibitor with IC50 of 0.37 nM, with >1000-fold selectivity over the PDE.
M3437 Cilomilast Cilomilast is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity.
M3434 Pimobendan Pimobendan is a selective inhibitor of PDE3 with IC50 of 0.32 μM.
M3394 Deltarasin Deltarasin is a novel small molecule which inhibits the KRAS-PDEδ interaction and thus impairing oncogenic KRAS signalling.
M3375 S-(+)-Rolipram S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous system, less potent than its R enantiomer.
M3337 Milrinone Milrinone is a potent and selective phosphodiesterase 3 inhibitor with an IC50 of 0.42 μM for the inhibition of FIII PDE.
M3259 Irsogladine Irsogladine is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding.
M2764 Ibudilast Ibudilast is a potent PDE4 inhibitor for PDE4A with IC50 of 54 nM.
M2410 Avanafil Avanafil is a highly selective PDE5 inhibitor with IC50 of 5.2 nM, >121-fold selectivity over other PDEs.
M2395 Anagrelide hydrochloride Anagrelide is a compound used for the treatment of essential thrombocytosis.
M2337 AN2728 AN2728 is a topical anti-inflammatory product candidate for the treatment of psoriasis and atopic dermatitis.
M2286 Sildenafil citrate Sildenafil citrate is an agent used to treat erectile dysfunction and pulmonary arterial hypertension (PAH).
M2030 Apremilast Apremilast is a novel, orally available small molecule inhibitor of PDE4 with IC50 of 74 nM.
M1906 Piclamilast Piclamilast (RP 73401) is a potent and selective inhibitor of phosphodiesterase (PDE) 4.
M1871 Roflumilast Roflumilast (trade names Daxas, Daliresp) is a novel and selective, long-acting inhibitor of phosphodiesterase 4 (PDE-4).
M1734 BAY-60-7550 BAY-60-7550 is a potent PDE2 inhibitor with IC50 values of 2.0 nM (bovine) and 4.7 nM (human).
M1728 GSK256066 GSK256066 is a selective phosphodiesterase 4 (PDE4)inhibitor with an IC50 of 3.2 pM.

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