Free shipping on all orders over $ 500

PDE Phosphodiesterase

Inhibitors

Cat.No.  Name Information
M2030 Apremilast Apremilast is a novel, orally available small molecule inhibitor of PDE4 with IC50 of 74 nM.
M11109 3-O-Methylquercetin 3-O-Methylquercetin (3-MQ), a main constituent of Rhamnus nakaharai, inhibits total cAMP and cGMP-phosphodiesterase (PDE) of guinea pig trachealis. 3-O-Methylquercetin (3-MQ) exhibits IC50 values of 31.9 μM, 86.9 μM, 18.6 μM and 1.6 μM for PDE1, PDE5, PDE2 and PDE4, respectively.
M10517 D159687 D159687 is a selective negative allosteric modulator (NAM) of PDE4D.
M10435 Difamilast Difamilast (OPA-15406) is a topical, highly selective and nonsteroidal phosphodiesterase-4 (PDE4) inhibitor.
M10179 Vesnarinone Vesnarinone is a cardiotonic agent, mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity.
M9882 Roflumilast N-oxide Roflumilast N-oxide is a phosphodiesterase 4 inhibitor.
M9679 CP671305 CP671305 is a potent and selective, orally active inhibitor of phosphodiesterase-4-D with high activities.
M9347 ITI-214 phosphate ITI-214 phosphate is an orally active, potent and selective inhibitors of PDE1, exhibits potent PDE1 inhibitory activity (Ki = 58 pM).
M6804 IBMX IBMX is a pDE inhibitor (non-selective) with IC50 values of 6.5±1.2, 26.3±3.9 and 31.7±5.3 μM for PDE3, 4 and 5 respectively.
M6287 GLPG1690 GLPG1690 (Ziritaxestat) is a first-in-class autotaxin (ATX) inhibitor, with IC50 of 131 nM and Ki of 15 nM.
M6153 E6005 RVT-501 (E6005) is a selective phosphodiesterase 4 (PDE4PDE4) inhibitor with an IC50 of 2.8 nM.
M6048 Vardenafil HCl Vardenafil Hcl is a PDE5 inhibitor used for treating erectile dysfunction.
M6042 Udenafil Udenafil(DA8159) is a PDE5 inhibitor used in urology to treat erectile dysfunction.
M6007 Theophylline Theophylline is a methylated xanthine derivative; competitive nonselective phosphodiesterase inhibitor and nonselective adenosine receptor antagonist.
M5960 Sildenafil Mesylate Sildenafil Mesylate is a mesylate form of Sildenafil, an inhibitor of Phosphodiesterase 5.
M5959 Sildenafil Sildenafil is a Phosphodiesterase 5 Inhibitor with IC50 of 5.22 nM.
M5939 Rolipram A selective inhibitor of PDE4, Rolipram, inhibits immunopurified PDE4B and PDE4D activity with IC50 of 130 nM and 240 nM, respectively. It has anti-inflammatory activity. Rolipram also increased cAMP levels and activated PKA, which in turn increased proteasome activity and inhibited tau aggregation.
M5519 Cilostazol Cilostazol is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake.
M4964 HA130 HA130 is a selective ATX (autotaxin) inhibitor with IC50 of 28 nM.
M4851 TAK-063 TAK-063 is a highly potent, selective and orally active PDE10A inhibitor with IC50 of 0.30 nM.
M3700 PF8380 Pf-8380 is a potent autotaxin inhibitor with IC50 of 2.8 nM and 101 nM in in vitro enzyme assay and human whole blood cell assay, respectively.



Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.