Free shipping on all orders over $ 500

IBMX

Cat. No. M6804
IBMX Structure
Synonym:

IMX; Isobutylmethylxanthine; Methylisobutylxanthine; NSC165960; SC2964

Size Price Availability Quantity
10mM*1mL In DMSO USD 65 In stock
50mg USD 65 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
Biological Activity

IBMX is a phosphodiesterase inhibitor (IC50 values are 13, 18, 19, 32 and 50 μM for PDE4, PDE3, PDE1, PDE5 and PDE2 respectively). IBMX suppresses α-adrenoceptor-mediated 5-HT release from neuroendocrine epithelial cells (IC50 = 1.3 μM). IBMX (100 μM) activates renal outer medullary K+ (ROMK) channels (n=6, P<0.05) and prevents further channel activation by ANG II (n=6, P=NS) or cGMP.

Treatments with IBMX and Apocynin significantly decrease cold-induced elevation of right ventricular (RV) systolic pressure (23.5±1.8 and 24.2±0.6 mmHg, respectively) although they do not decrease RV pressure to the warm control levels. IBMX or Apocynin significantly reduces medial layer thickness (19.0±0.9, and 16.9±0.8 μm, respectively) and increases lumen diameter (62.7±4.2, and 59.5±4.3 μm, respectively) of small PAs in cold-exposed rats.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 222.24
Formula C10H14N4O2
CAS Number 28822-58-4
Purity 99.75%
Solubility DMSO: ≥ 32 mg/mL
Storage at -20°C
References

The phosphodiesterase inhibitor isobutylmethylxanthine attenuates behavioral sensitization to cocaine.
Schroeder JA, et al. Behav Pharmacol. 2012 Jun;23(3):310-4. PMID: 22495185.

KMUP-1, a xanthine derivative, induces relaxation of guinea-pig isolated trachea: the role of the epithelium, cyclic nucleotides and K+ channels.
Wu BN, et al. Br J Pharmacol. 2004 Aug;142(7):1105-14. PMID: 15237094.

Related PDE Products
CP671305

CP671305 is a potent and selective, orally active inhibitor of phosphodiesterase-4-D with high activities.

ITI-214 phosphate

ITI-214 phosphate is an orally active, potent and selective inhibitors of PDE1, exhibits potent PDE1 inhibitory activity (Ki = 58 pM).

GLPG1690

GLPG1690 (Ziritaxestat) is a first-in-class autotaxin (ATX) inhibitor, with IC50 of 131 nM and Ki of 15 nM.

E6005

RVT-501 (E6005) is a selective phosphodiesterase 4 (PDE4PDE4) inhibitor with an IC50 of 2.8 nM.

Vardenafil HCl

Vardenafil Hcl is a PDE5 inhibitor used for treating erectile dysfunction.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: IBMX, IMX; Isobutylmethylxanthine; Methylisobutylxanthine; NSC165960; SC2964 supplier, PDE, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.