Mirodenafil is a newly developed oral type 5 phosphodiesterase inhibitor. mirodenafil is a modulator of the glucocorticoid receptor (GR). mirodenafil activates the Wnt/β-catenin signaling pathway by downregulating the expression of Dkk1. mirodenafil can be used to study erectile dysfunction (ED), Alzheimer's disease (AD) and systemic sclerosis (SSc). Mirodenafil can be used to study erectile dysfunction (ED), Alzheimer's disease (AD), and systemic sclerosis (SSc).
| Molecular Weight | 531.67 |
| Formula | C26H37N5O5S |
| CAS Number | 862189-95-5 |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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