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(+)Gomisin-M2

Cat. No. M4254
(+)Gomisin-M2 Structure
Synonym:

CAS# 100759-78-2

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Biological Activity

(+)Gomisin-M2

Another CAS#:100759-78-2

Chemical Information
Molecular Weight 386.43
Formula C22H26O6
CAS Number 82425-45-4
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Namkyung Kim, et al. Gomisin M2 alleviates psoriasis‑like skin inflammation by inhibiting inflammatory signaling pathways

[2] Jinjoo Kang, et al. Gomisin M2 Ameliorates Atopic Dermatitis-like Skin Lesions via Inhibition of STAT1 and NF-κB Activation in 2,4-Dinitrochlorobenzene/ Dermatophagoides farinae Extract-Induced BALB/c Mice

[3] Yeguo Yang, et al. Gomisin M2 from Baizuan suppresses breast cancer stem cell proliferation in a zebrafish xenograft model

[4] Hima Dhakal, et al. Gomisin M2 Inhibits Mast Cell-Mediated Allergic Inflammation via Attenuation of FcεRI-Mediated Lyn and Fyn Activation and Intracellular Calcium Levels

[5] Min Chen, et al. Rubrisandrins A and B, lignans and related anti-HIV compounds from Schisandra rubriflora

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Keywords: (+)Gomisin-M2, CAS# 100759-78-2 supplier, Others, inhibitors, activators

 
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