Plantamajoside is a hydroxycinnamic acid, which used as a biomarker in chemotaxonomical studies.
 |
Source | BMC Complement Altern Med (2017). Figure 2. Plantamajoside |
| Method | Western blotting | |
| Cell Lines | HUVECs | |
| Concentrations | 10 μM | |
| Incubation Time | 24 h | |
| Results | In contrast, the co-treatment with 10 μM PM and 100 μg/mLof glycer-AGEs reduced protein expression |
 |
Source | BMC Complement Altern Med (2017). Figure 1. Plantamajoside |
| Method | MTT assay | |
| Cell Lines | HUVECs | |
| Concentrations | 10 μM | |
| Incubation Time | 24 h | |
| Results | We checked the PM cytotoxicity at 100 μM PM for 24 h and then treated with the PM only up to 10 μM PM after all experiments; NAC was not cytotoxic up to 1 mM for 24 h |
| Cell Experiment | |
|---|---|
| Cell lines | MDA-MB-231 cells and 4T1 cells |
| Preparation method | Cell viability assay was also performed on CHO cells to investigate the side effect of PMS on normal cells. The PMS concentration closed to IC50 (data not shown) for MDA-MB-231 cells and 4T1 cells at 36 h time point was chosen to treat CHO. |
| Concentrations | 100 μg/mL |
| Incubation time | 36 h |
| Animal Experiment | |
|---|---|
| Animal models | BALB/c mice |
| Formulation | |
| Dosages | 200 mg/kg |
| Administration | oral |
| Molecular Weight | 640.59 |
| Formula | C29H36O16 |
| CAS Number | 104777-68-6 |
| Solubility (25°C) | DMSO: ≥ 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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