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Pilocarpine hydrochloride

Cat. No. M2944
Pilocarpine hydrochloride Structure
Size Price Availability Quantity
100mg USD 40  USD40 In stock
500mg USD 96  USD96 In stock
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Quality Control & Documentation
Biological Activity

Pilocarpine hydrochloride is a nonselective muscarinic acetylcholine receptor agonist used to produce an experimental model of epilepsy.

*The compound is unstable in solutions, freshly prepared is recommended

Chemical Information
Molecular Weight 244.72
Formula C11H16N2O2.HCl
CAS Number 54-71-7
Solubility (25°C) Water 30 mg/mL
DMSO 10 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Eyal Zur. Low-dose Pilocarpine Spray to Treat Xerostomia

[2] Christopher Nile, et al. Repurposing Pilocarpine Hydrochloride for Treatment of Candida albicans Infections

[3] Kazuyasu Maruyama, et al. Pharmacological and clinical profile of pilocarpine hydrochloride (SALAGEN) Tab. 5 mg)

[4] Susan Bruce. Pilocarpine hydrochloride

[5] T J Zimmerman. Pilocarpine

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