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Benzbromarone

Cat. No. M2440
Benzbromarone Structure
Size Price Availability Quantity
100mg USD 60  USD60 In stock
200mg USD 100  USD100 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Benzbromarone is a CYP2C9 inhibitor, it binds to CYP2C9 with Ki value of 19.3 nM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 424.08
Formula C17H12Br2O3
CAS Number 3562-84-3
Purity >99%
Solubility DMSO 80 mg/mL
Storage at -20°C
References

[1] Esraa Abdel-Nassir Abdel-Razek, et al. Benzbromarone mitigates cisplatin nephrotoxicity involving enhanced peroxisome proliferator-activated receptor-alpha (PPAR-α) expression

[2] No authors listed. Benzbromarone

[3] Valderilio Feij Azevedo, et al. Benzbromarone in the treatment of gout

[4] Peng Sun, et al. Benzbromarone aggravates hepatic steatosis in obese individuals

[5] Ming-Han H Lee, et al. A benefit-risk assessment of benzbromarone in the treatment of gout. Was its withdrawal from the market in the best interest of patients?

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Keywords: Benzbromarone supplier, Cytochrome P450 (e.g. CYP17), inhibitors

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