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Onjixanthone I

Cat. No. M17910
Onjixanthone I Structure
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Onjixanthone I

Chemical Information
CAS Number 136083-92-6
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Shi-Jie Su, et al. Zhongguo Zhong Yao Za Zhi. [Exploration on mechanism of Polygalae Radix and Acori Tatarinowii Rhizoma in treating Alzheimer's disease based on network pharmacology and experimental verification]

[2] Ke-Zhu Wu, et al. Interdiscip Sci. Establishment of the method for screening the potential targets and effective components of huatuo reconstruction pill

[3] Yu-Hong Zhou, et al. Chin J Nat Med. Chemical investigation of the roots of Polygala sibirica L

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