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Gentisin

Cat. No. M17922
Gentisin Structure
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Biological Activity

Gentisin

Chemical Information
CAS Number 437-50-3
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] FEEDAP, et al. EFSA J. Safety and efficacy of a feed additive consisting of a tincture derived from roots of Gentiana lutea L. (gentian tincture) for use in all animal species (FEFANA asbl)

[2] Jiayan Wu, et al. Evid Based Complement Alternat Med. A Network Pharmacology-Based Study on the Anti-Lung Cancer Effect of Dipsaci Radix

[3] Cheng-Peng Sun, et al. Int J Biol Macromol. The study of inhibitory effect of natural flavonoids toward β-glucuronidase and interaction of flavonoids with β-glucuronidase

[4] Ivana Citov, et al. J Sep Sci. Determination of gentisin, isogentisin, and amarogentin in Gentiana lutea L. by capillary electrophoresis

[5] I Morimoto, et al. Mutat Res. Mutagenic activities of gentisin and isogentisin from Gentianae radix (Gentianaceae)

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