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Norathyriol

Cat. No. M17917
Norathyriol Structure
Size Price Availability Quantity
5mg USD 450  USD450 In stock
10mg USD 780  USD780 In stock
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Quality Control & Documentation
Biological Activity

Norathyriol

Chemical Information
CAS Number 3542-72-1
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Uswatun Hasanah, et al. Biosci Biotechnol Biochem. Aerobic bioconversion of C-glycoside mangiferin into its aglycone norathyriol by an isolated mouse intestinal bacterium

[2] Hua Lin, et al. Eur J Pharmacol. Dual actions of norathyriol as a new candidate hypouricaemic agent: uricosuric effects and xanthine oxidase inhibition

[3] Xiaozhen Guo, et al. J Agric Food Chem. Absorption, Metabolism, and Pharmacokinetics Profiles of Norathyriol, an Aglycone of Mangiferin, in Rats by HPLC-MS/MS

[4] Zhi-Long Shi, et al. Biochem Res Int. In Vitro and In Vivo Effects of Norathyriol and Mangiferin on α-Glucosidase

[5] Jixia Li, et al. J Cancer Res Ther. Norathyriol suppresses transformation in JB6 P+ cells by the inhibition of Akt

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