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Euxanthone

Cat. No. M17919
Euxanthone Structure
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Biological Activity

Euxanthone

Chemical Information
CAS Number 529-61-3
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Wei Sun, et al. Cent Eur J Immunol. Euxanthone improves cognitive impairment by attenuating mitochondrial fragmentation and suppressing oxidative stress

[2] Shengnan Li, et al. Life Sci. Retraction notice to "Cytoprotective effects of euxanthone against ox-LDL-induced endothelial cell injury is mediated via Nrf2" [Life Sci. 223 (2019) 174-184]

[3] Wen Li, et al. Anat Rec (Hoboken). Euxanthone represses the proliferation, migration, and invasion of glioblastoma cells by modulating STAT3/SHP-1 signaling

[4] Hui Zhou, et al. J Mol Neurosci. Euxanthone Ameliorates Sevoflurane-Induced Neurotoxicity in Neonatal Mice

[5] Xiaodong Chen, et al. Anat Rec (Hoboken). Euxanthone Impairs the Metastatic Potential of Osteosarcoma by Reducing COX-2 Expression

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