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Angustin A

Cat. No. M17921
Angustin A Structure
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Biological Activity

Angustin A

Chemical Information
CAS Number 1415795-50-4
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Christian Augsberger, et al. Blood. Targeting intracellular WT1 in AML with a novel RMF-peptide-MHC-specific T-cell bispecific antibody

[2] Friederika Fluck, et al. Rofo. Current Treatment Options in Acute Limb Ischemia

[3] Anne Marie Augustin, et al. Rofo. Endovascular Therapy of Gastrointestinal Bleeding

[4] David S Boyer, et al. Ophthalmology. Three-year, randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with diabetic macular edema

[5] D Barnes-Josiah, et al. Soc Sci Med. The "three delays" as a framework for examining maternal mortality in Haiti

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