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Neoisoliquiritin

Cat. No. M18594
Neoisoliquiritin Structure
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Biological Activity

Neoisoliquiritin

Chemical Information
CAS Number 7014-39-3
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Ahmed M Tolah, et al. Pharmaceuticals (Basel). Computational and In Vitro Experimental Investigations Reveal Anti-Viral Activity of Licorice and Glycyrrhizin against Severe Acute Respiratory Syndrome Coronavirus 2

[2] Changbao Chen, et al. Phytomedicine. Neoisoliquiritin exerts tumor suppressive effects on prostate cancer by repressing androgen receptor activity

[3] Yuanjie Li, et al. J Neuroinflammation. Isoliquiritin ameliorates depression by suppressing NLRP3-mediated pyroptosis via miRNA-27a/SYK/NF-κB axis

[4] Tingting Li, et al. J Anal Methods Chem. Spectrum-Effect Relationships of Flavonoids in Glycyrrhiza uralensis Fisch

[5] Fu Peng, et al. Biomed Chromatogr. The application of HPLC-MS/MS to studies of pharmacokinetics and interconversion of isoliquiritigenin and neoisoliquiritigenin in rats

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