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Naringenin triacetate

Cat. No. M18357
Naringenin triacetate Structure
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Biological Activity

Naringenin triacetate

Chemical Information
CAS Number 3682-04-0
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Emily K Bowman, et al. Proc Natl Acad Sci U S A. Sorting for secreted molecule production using a biosensor-in-microdroplet approach

[2] Claire M Palmer, et al. Metab Eng. Engineering 4-coumaroyl-CoA derived polyketide production in Yarrowia lipolytica through a β-oxidation mediated strategy

[3] S K Mukherjee, et al. J Appl Microbiol. Effect of non-β-lactams on stable variants of inhibitor-resistant TEM β-lactamase in uropathogenic Escherichia coli: implication for alternative therapy

[4] Ayub Shaik, et al. Bioinformation. Molecular docking analysis of UniProtKB nitrate reductase enzyme with known natural flavonoids

[5] Yasunobu Yamashita, et al. Chem Pharm Bull (Tokyo). Simple Synthesis of Sakuranetin and Selinone via a Common Intermediate, Utilizing Complementary Regioselectivity in the Deacetylation of Naringenin Triacetate

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